Leupeptin cation

Base Information

• Chemical Name: Leupeptin cation
• CAS No.: 103476-89-7
• Molecular Formula: 2(C20H38N6O4)^.H2SO4
• Molecular Weight: 951.19
• Hs Code.: 29252900
• European Community (EC) Number: 600-443-5
• Mol file: 103476-89-7.mol

Synonyms:Leupeptin hemisulfate;103476-89-7;leupeptin cation;leupeptin(1+);CHEBI:192489;HB3958;C20H38N6O4.0.5H2SO4;PD087718;leupeptin hemisulfate from microbial*source;N-acetyl-L-leucyl-N-[(2S)-5-{[amino(iminio)methyl]amino}-1-oxopentan-2-yl]-L-leucinamide;Acetyl-Leu-Leu-Arg-al, Leupeptin hemisulfate salt, N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt

Chemical Property of Leupeptin cation

Chemical Property:

• Appearance/Colour: white or off-white powder
• Refractive Index: 1.557
• PSA: 166.27000
• Density: 1.21g/cm³
• LogP: 2.37870
• Storage Temp.: −20°C
• Solubility.: H2O: 10 mM Solutions are stable for a week at 4 °C.
• Water Solubility.: soluble
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 14
• Exact Mass: 427.30327875
• Heavy Atom Count: 30
• Complexity: 602

Purity/Quality:

Leupeptin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-63-36/37/38
• Safety Statements: 22-24/25-36/37-36-36/37/39-26-7/8

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCC[NH+]=C(N)N)C=O)NC(=O)C
• Isomeric SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC[NH+]=C(N)N)C=O)NC(=O)C
• Description: Leupeptin hemisulfate (103476-89-7) is a reversible inhibitor of trypsin-like proteases and cysteine proteases. Inhibits trypsin, plasmin, papain and cathepsin B, H and L.1-3?Blocks various apoptotic pathways in T cells.4?Commonly used in cell lysis buffers to protect proteins from degradation. Typical working concentration is 1μM (0.5 μg/ml).
• Uses: Reversible protease inhibitor, which inhibits cathepsin B, calpain and trypsinPharmaceutical composition containing leupeptin hemisulfate is used as an anti-malarial agent. It is employed in the treatment of noise-induced hearing loss. It also protects the heart from myocardial stunning. Further, it is used to inhibit serine, cysteine proteases, plasmin, trypsin, papain, kallikrein and cathepsin B. Leupeptin as well as other protease inhibitors like antipain, chymostatin, pepstatin, and phosphoramidon are useful for the protection of proteins during their isolation from tissues or membranes. Leupeptin can be removed from the reaction by dialysis.Note: To check other protease inhibitors, try our Protease Inhibitor Set including Antipain Dihydrochloride, Aprotinin, Bestatin, Chymostatin, E-64, EDTA-Na2, Leupeptin, Pefabloc SC, Pepstatin, and Phosphoramidon. Leupeptin has been used as a protease inhibitor: in ice-cold lysis buffer to harvest cells for western immunoblotting and immunoprecipitation,in chromatin immunoprecipitation (ChIP) lysis buffer for the isolation of fragmented chromatin samples in lysis buffer I to lyse the cells for tandem affinity purification (TAP)