Oxazole, 4-[(1E)-2-[(2R,3R,4S,5S,6R)-6-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy] ethyl]tetrahydro-4-[(4-methoxyphenyl)methoxy]-3,5-dimethyl-2H-pyran-2- yl]-1-propen-1-yl]-2-methyl-

Base Information

Chemical Name:Oxazole, 4-[(1E)-2-[(2R,3R,4S,5S,6R)-6-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy] ethyl]tetrahydro-4-[(4-methoxyphenyl)methoxy]-3,5-dimethyl-2H-pyran-2- yl]-1-propen-1-yl]-2-methyl-
CAS No.:920034-26-0
Molecular Formula:C30H47NO5Si
Molecular Weight:529.792
Hs Code.:

Oxazole,
4-[(1E)-2-[(2R,3R,4S,5S,6R)-6-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]
ethyl]tetrahydro-4-[(4-methoxyphenyl)methoxy]-3,5-dimethyl-2H-pyran-2-
yl]-1-propen-1-yl]-2-methyl-

Synonyms:

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Chemical Property of Oxazole, 4-[(1E)-2-[(2R,3R,4S,5S,6R)-6-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy] ethyl]tetrahydro-4-[(4-methoxyphenyl)methoxy]-3,5-dimethyl-2H-pyran-2- yl]-1-propen-1-yl]-2-methyl-

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MSDS Files:: SDS file from LookChem

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Technology Process of Oxazole, 4-[(1E)-2-[(2R,3R,4S,5S,6R)-6-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy] ethyl]tetrahydro-4-[(4-methoxyphenyl)methoxy]-3,5-dimethyl-2H-pyran-2- yl]-1-propen-1-yl]-2-methyl-

There total 9 articles about Oxazole, 4-[(1E)-2-[(2R,3R,4S,5S,6R)-6-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy] ethyl]tetrahydro-4-[(4-methoxyphenyl)methoxy]-3,5-dimethyl-2H-pyran-2- yl]-1-propen-1-yl]-2-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 920034-37-3
(2R,3R,4S,5R,6R,E)-2-(2-(tert-butyldimethylsilyloxy)ethyl)-3,5-dimethyl-6-(1-(2-methyloxazol-4-yl)prop-1-en-2-yl)-tetrahydro-2H-pyran-4-ol

: 824-94-2
p-methoxybenzyl chloride

: 920034-26-0
4-((E)-2-((2R,3R,4S,5S,6R)-6-(2-(tert-butyldimethylsilanyloxy)ethyl)-4-(4-methoxybenzyloxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)prop-1-enyl)-2-methyloxazole

Guidance literature:: (2R,3R,4S,5R,6R,E)-2-(2-(tert-butyldimethylsilyloxy)ethyl)-3,5-dimethyl-6-(1-(2-methyloxazol-4-yl)prop-1-en-2-yl)-tetrahydro-2H-pyran-4-ol; With sodium hydride; In tetrahydrofuran; for 15h; Heating;

p-methoxybenzyl chloride; In tetrahydrofuran; for 4.5h; Heating;
DOI:10.1021/ol062531j

Reference yield:

: 920034-38-4
2-(2-hydroxy-ethyl)-3,5-dimethyl-6-[1-methyl-2-(2-methyl-oxazol-4-yl)-vinyl]-tetrahydro-pyran-4-ol

: 920034-26-0
4-((E)-2-((2R,3R,4S,5S,6R)-6-(2-(tert-butyldimethylsilanyloxy)ethyl)-4-(4-methoxybenzyloxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)prop-1-enyl)-2-methyloxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / N,N-diisopropylethylamine; 4-dimethylaminopyridine / CH₂Cl₂ / 12 h

2.1: sodium hydride / tetrahydrofuran / 15 h / Heating

2.2: 95 percent / tetrahydrofuran / 4.5 h / Heating

With dmap; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol062531j

Reference yield:

: 391208-65-4
(2R,3S,4S,5S,6R)-3,5-dimethyl-6-[(1E)-1-methyl-2-(2-methyloxazol-4-yl)vinyl]-4-triisopropylsilanyloxytetrahydropyran-2-ylethanol

: 920034-26-0
4-((E)-2-((2R,3R,4S,5S,6R)-6-(2-(tert-butyldimethylsilanyloxy)ethyl)-4-(4-methoxybenzyloxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)prop-1-enyl)-2-methyloxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 0 °C

2.1: 99 percent / N,N-diisopropylethylamine; 4-dimethylaminopyridine / CH₂Cl₂ / 12 h

3.1: sodium hydride / tetrahydrofuran / 15 h / Heating

3.2: 95 percent / tetrahydrofuran / 4.5 h / Heating

With dmap; tetrabutyl ammonium fluoride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol062531j