1,24,25-trihydroxyvitamin D3

Base Information

Chemical Name:1,24,25-trihydroxyvitamin D3
CAS No.:50648-94-7
Molecular Formula:C₂₇H₄₄O₄
Molecular Weight:432.644
Hs Code.:
DSSTox Substance ID:DTXSID40432720
Mol file:50648-94-7.mol

Synonyms:1,24,25-trihydroxycholecalciferol;1,24,25-trihydroxyvitamin D3;1,24,25-trihydroxyvitamin D3, (1alpha,3beta,5Z,7E)-isomer;1,24,25-trihydroxyvitamin D3, (1alpha,3beta,5Z,7E,24R)-isomer;1,24,25-trihydroxyvitamin D3, (1alpha,3beta,5Z,7E,24S)-isomer;1,24,25-trihydroxyvitamin D3, (3beta,5Z,7E,24R)-isomer

Suppliers and Price of 1,24,25-trihydroxyvitamin D3

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1,24,25-trihydroxyvitamin D3

Chemical Property:

Vapor Pressure:2.6E-17mmHg at 25°C
Boiling Point:607.8°C at 760 mmHg
Flash Point:258.5°C
PSA：80.92000
Density:1.1g/cm³
LogP:4.67550
XLogP3:3.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:432.32395988
Heavy Atom Count:31
Complexity:721

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CCC(C(C)(C)O)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
Isomeric SMILES:C[C@H](CCC(C(C)(C)O)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C

Technology Process of 1,24,25-trihydroxyvitamin D3

There total 14 articles about 1,24,25-trihydroxyvitamin D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55721-11-4,272776-87-1
24(R),25-dihydroxycholecalciferol

: 50648-94-7,56142-94-0,56142-95-1,65375-95-3,65375-96-4,72203-93-1,73837-27-1,78684-65-8
(1alpha,24R,25)-trihydroxy-Vitamin D₃

Guidance literature:: With D-glucose 6-phosphate; bovine adrenodoxin reductase; mouse 25-hydroxyvitamin D3 1α-hydroxylase; mouse adrenodoxin; water; NADPH; glucose 6-phosphate dehydrogenase; at 37 ℃; pH=7.4; Concentration; Kinetics; aq. buffer; phospholipid vesicles; Enzymatic reaction;
DOI:10.1016/j.jsbmb.2010.02.022

Reference yield:

: 474432-43-4
(1α,3β,5Z,7E,24R)-1,3-di[(tert-butyldimethylsilyl)oxy]-9,10-secocholesta-5,7,10(9)-triene-24,25-diol cyclic 24,25-(1-methylethylidene acetal)

: 50648-94-7,56142-94-0,56142-95-1,65375-95-3,65375-96-4,72203-93-1,73837-27-1,78684-65-8
(1alpha,24R,25)-trihydroxy-Vitamin D₃

Guidance literature:: Multi-step reaction with 2 steps

1: nBu₄NF*3H₂O / tetrahydrofuran / 22 h

2: AG 50W-X₄ resin / methanol / 22 h

With AG 50W-X₄ resin; tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol;
DOI:10.1002/1521-3765(20020617)8:12<2747::AID-CHEM2747>3.0.CO;2-J

Reference yield:

: 226569-00-2
(1R,3aR,4S,7aR)-1-[(1R,4R)-4,5-dihydroxy-1,5-dimethylhexyl]-7a-methyl-octahydro-1H-inden-4-ol

: 50648-94-7,56142-94-0,56142-95-1,65375-95-3,65375-96-4,72203-93-1,73837-27-1,78684-65-8
(1alpha,24R,25)-trihydroxy-Vitamin D₃

Guidance literature:: Multi-step reaction with 5 steps

1.1: 89 percent / aq. H₂SO₄ / acetone / 2.5 h / ultrasonication

2.1: 99 percent / PDC / CH₂Cl₂ / 6 h

3.1: nBuLi / hexane; tetrahydrofuran / 5 h / -78 - 0 °C

3.2: 92 percent / tetrahydrofuran; hexane / 5 h / 20 °C

4.1: nBu₄NF*3H₂O / tetrahydrofuran / 22 h

5.1: AG 50W-X₄ resin / methanol / 22 h

With dipyridinium dichromate; n-butyllithium; AG 50W-X₄ resin; sulfuric acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; hexane; dichloromethane; acetone; 3.1: Wittig-Horner reaction / 3.2: Wittig-Horner reaction;
DOI:10.1002/1521-3765(20020617)8:12<2747::AID-CHEM2747>3.0.CO;2-J