(2,3-Dihydro-1H-inden-1-yl)(5-fluoro-2-methoxyphenyl)methanone

Base Information

Chemical Name:(2,3-Dihydro-1H-inden-1-yl)(5-fluoro-2-methoxyphenyl)methanone
CAS No.:920508-14-1
Molecular Formula:C17H15FO2
Molecular Weight:270.303
Hs Code.:
DSSTox Substance ID:DTXSID90582300

Synonyms:920508-14-1;DTXSID90582300;(2,3-Dihydro-1H-inden-1-yl)(5-fluoro-2-methoxyphenyl)methanone;AKOS021087504

Suppliers and Price of (2,3-Dihydro-1H-inden-1-yl)(5-fluoro-2-methoxyphenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of (2,3-Dihydro-1H-inden-1-yl)(5-fluoro-2-methoxyphenyl)methanone

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:270.10560788
Heavy Atom Count:20
Complexity:357

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)F)C(=O)C2CCC3=CC=CC=C23

Technology Process of (2,3-Dihydro-1H-inden-1-yl)(5-fluoro-2-methoxyphenyl)methanone

There total 4 articles about (2,3-Dihydro-1H-inden-1-yl)(5-fluoro-2-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 848170-27-4
indan-1-carboxylic acid methoxy-methyl-amide

: 452-08-4
2-bromo-4-fluoro-1-methoxybenzene

: 920508-14-1
(5-fluoro-2-methoxy-phenyl)-indan-1-yl-methanone

Guidance literature:: 2-bromo-4-fluoro-1-methoxybenzene; With n-butyllithium; In diethyl ether; at -78 ℃;

indan-1-carboxylic acid methoxy-methyl-amide; In diethyl ether;
DOI:10.1002/anie.200601569

Reference yield:

: lithium; indan-1-carboxylate

: 452-08-4
2-bromo-4-fluoro-1-methoxybenzene

: 920508-14-1
(5-fluoro-2-methoxy-phenyl)-indan-1-yl-methanone

Guidance literature:: 2-bromo-4-fluoro-1-methoxybenzene; With n-butyllithium; In diethyl ether; at -78 ℃;

lithium; indan-1-carboxylate; In diethyl ether;
DOI:10.1002/anie.200601569

Reference yield:

: 14381-42-1
Indan-1-carboxylic acid

: 920508-14-1
(5-fluoro-2-methoxy-phenyl)-indan-1-yl-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: SOCl₂ / Heating

2.1: pyridine / 0 - 20 °C

3.1: nBuLi / diethyl ether / -78 °C

3.2: diethyl ether

With pyridine; n-butyllithium; thionyl chloride; In diethyl ether;
DOI:10.1002/anie.200601569