4-hydroxy-2-(4-methylphenyl)benzothiazole

Base Information

• Chemical Name: 4-hydroxy-2-(4-methylphenyl)benzothiazole
• CAS No.: 122589-83-7
• Molecular Formula: C14H11 N O S
• Molecular Weight: 241.31
• Mol file: 122589-83-7.mol

Synonyms:KB 2714

Chemical Property of 4-hydroxy-2-(4-methylphenyl)benzothiazole

Chemical Property:

• Vapor Pressure: 6.65E-08mmHg at 25°C
• Boiling Point: 427.3°Cat760mmHg
• Flash Point: 212.2°C
• PSA: 61.36000
• Density: 1.295g/cm³
• LogP: 3.97730

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-hydroxy-2-(4-methylphenyl)benzothiazole

There total 6 articles about 4-hydroxy-2-(4-methylphenyl)benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-methoxy-2-(4-methylphenyl)benzothiazole (122589-86-0) → 4-hydroxy-2-(4-methylphenyl)benzothiazole (122589-83-7)

Guidance literature:

With aluminium(III) iodide; tetra-(n-butyl)ammonium iodide; In benzene; for 7h; Heating;

DOI:10.1248/cpb.40.2387

Reference yield:

4-methyl-benzoyl chloride (874-60-2) → 4-hydroxy-2-(4-methylphenyl)benzothiazole (122589-83-7)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / tetrahydrofuran / 1 h / Ambient temperature

2: 60 percent / Lawesson's reagent / toluene / 1 h / Heating

3: 56 percent / potassium hydroxide, potassium ferricyanide / H₂O / 6 h / Ambient temperature

4: 72 percent / AlI₃, tetra-n-butylammonium iodide / benzene / 7 h / Heating

With Lawessons reagent; pyridine; potassium hydroxide; aluminium(III) iodide; tetra-(n-butyl)ammonium iodide; potassium hexacyanoferrate(III); In tetrahydrofuran; water; toluene; benzene;

DOI:10.1248/cpb.40.2387

Reference yield:

p-Toluic acid (99-94-5) → 4-hydroxy-2-(4-methylphenyl)benzothiazole (122589-83-7)

Guidance literature:

Multi-step reaction with 5 steps

1: DMF, thionyl chloride / 3 h / Heating

2: pyridine / tetrahydrofuran / 1 h / Ambient temperature

3: 60 percent / Lawesson's reagent / toluene / 1 h / Heating

4: 56 percent / potassium hydroxide, potassium ferricyanide / H₂O / 6 h / Ambient temperature

5: 72 percent / AlI₃, tetra-n-butylammonium iodide / benzene / 7 h / Heating

With Lawessons reagent; pyridine; potassium hydroxide; aluminium(III) iodide; thionyl chloride; tetra-(n-butyl)ammonium iodide; N,N-dimethyl-formamide; potassium hexacyanoferrate(III); In tetrahydrofuran; water; toluene; benzene;

DOI:10.1248/cpb.40.2387

upstream raw materials:

4-methoxy-2-(4-methylphenyl)benzothiazole

4-methyl-benzoyl chloride

p-Toluic acid

N-(2-methoxyphenyl)-4-methyl-benzamide

Downstream raw materials:

4-acetoxy-2-(4-methylphenyl)benzothiazole