Technology Process of Cyclohexanecarboxylic acid, 1-[(1-methoxy-2-naphthalenyl)methyl]-,
methyl ester
There total 1 articles about Cyclohexanecarboxylic acid, 1-[(1-methoxy-2-naphthalenyl)methyl]-,
methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl cyclohexylcarboxylate;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran;
at -78 ℃;
Inert atmosphere;
2-(bromomethyl)-1-methoxynaphthalene;
With
N,N,N,N,N,N-hexamethylphosphoric triamide;
In
tetrahydrofuran;
at -78 ℃;
for 2h;
Inert atmosphere;
DOI:10.1271/bbb.90946
- Guidance literature:
-
Multi-step reaction with 2 steps
1: aluminum (III) chloride / chlorobenzene / 3 h / Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling with ice
With
aluminum (III) chloride; lithium aluminium tetrahydride;
In
tetrahydrofuran; chlorobenzene;
DOI:10.1271/bbb.90946
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / chlorobenzene / 3 h / Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling with ice
3.1: potassium nitrososulfonate; sodium acetate / methanol; water; N,N-dimethyl-formamide / 5 h / 20 °C
4.1: toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone / benzene / 1 h / Reflux
5.1: sodium hydroxide / water / 1 h / Reflux
5.2: 20 °C / pH 7
With
aluminum (III) chloride; lithium aluminium tetrahydride; potassium nitrososulfonate; sodium acetate; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; chlorobenzene; benzene;
DOI:10.1271/bbb.90946
