N-(cyclohexylmethyl)-N'-phenylurea

Base Information

• Chemical Name: N-(cyclohexylmethyl)-N'-phenylurea
• CAS No.: 92373-98-3
• Molecular Formula: C14H20N2O
• Molecular Weight: 232.326
• European Community (EC) Number: 652-972-6
• ChEMBL ID: CHEMBL3661376
• Nikkaji Number: J1.360.570J
• Pharos Ligand ID: J7YDAQMXL4RP
• Mol file: 92373-98-3.mol

Synonyms:N-(cyclohexylmethyl)-N'-phenylurea;CHEMBL3661376;SCHEMBL12196136;BDBM129286;AKOS004044880;US8815951, 176

Chemical Property of N-(cyclohexylmethyl)-N'-phenylurea

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 232.157563266
• Heavy Atom Count: 17
• Complexity: 230

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)CNC(=O)NC2=CC=CC=C2

Technology Process of N-(cyclohexylmethyl)-N'-phenylurea

There total 7 articles about N-(cyclohexylmethyl)-N'-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

phenyl isocyanate (103-71-9) + cyclohexylmethylamine (3218-02-8) → N-cyclohexylmethyl-N'-phenyl-urea (92373-98-3)

Guidance literature:

In toluene; at 100 ℃; for 1h;

DOI:10.1039/c9md00122k

Reference yield:

cyclohexylmethylamine (3218-02-8) + benzoyl azide (582-61-6) → N-cyclohexylmethyl-N'-phenyl-urea (92373-98-3)

Guidance literature:

benzoyl azide; In toluene; at 100 ℃; for 2h;

In toluene; at 100 ℃;

cyclohexylmethylamine; With triethylamine; In acetonitrile; at 70 ℃; Further stages.;

DOI:10.1016/j.tetlet.2007.05.050

Reference yield:

cyclohexylmethylamine (3218-02-8) → N-cyclohexylmethyl-N'-phenyl-urea (92373-98-3)

Guidance literature:

Multi-step reaction with 2 steps

2: benzene

In benzene;

DOI:10.1111/j.2042-7158.1964.tb07510.x

upstream raw materials:

phenyl isocyanate

cyclohexylmethylamine

aniline

cyclohexanemethyl isocyanate