Morphinan-6-one, 17-(cyclopropylmethyl)-3-hydroxy-14-(phenylmethyl)-

Base Information

Chemical Name:Morphinan-6-one, 17-(cyclopropylmethyl)-3-hydroxy-14-(phenylmethyl)-
CAS No.:109026-86-0
Molecular Formula:C27H31 N O2
Molecular Weight:0
Hs Code.:
DSSTox Substance ID:DTXSID20910970
Mol file:109026-86-0.mol

Synonyms:SDZ 210-096;SDZ-210-096

Suppliers and Price of Morphinan-6-one, 17-(cyclopropylmethyl)-3-hydroxy-14-(phenylmethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Morphinan-6-one, 17-(cyclopropylmethyl)-3-hydroxy-14-(phenylmethyl)-

Chemical Property:

Vapor Pressure:3.43E-14mmHg at 25°C
Boiling Point:583°Cat760mmHg
Flash Point:306.4°C
PSA：40.54000
Density:1.25g/cm³
LogP:4.59040
XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:401.235479232
Heavy Atom Count:30
Complexity:668

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1CN2CCC34CC(=O)CCC3(C2CC5=C4C=C(C=C5)O)CC6=CC=CC=C6
Isomeric SMILES:C1CC1CN2CCC34CC(=O)CCC3([C@H]2CC5=C4C=C(C=C5)O)CC6=CC=CC=C6

Technology Process of Morphinan-6-one, 17-(cyclopropylmethyl)-3-hydroxy-14-(phenylmethyl)-

There total 9 articles about Morphinan-6-one, 17-(cyclopropylmethyl)-3-hydroxy-14-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 109026-85-9
14β-benzyl-17-(cyclopropylmethyl)-3-methoxymorphinan-6-one

: 109026-86-0
14β-benzyl-17(cyclopropylmethyl)-3-hydroxymorphinan-6-one

Guidance literature:: With pyridine hydrochloride; at 170 ℃; for 5.5h;
DOI:10.1002/hlca.19900730212

Reference yield:

: 5083-80-7
N-(cyclopropylmethyl)northebaine

: 109026-86-0
14β-benzyl-17(cyclopropylmethyl)-3-hydroxymorphinan-6-one

Guidance literature:: Multi-step reaction with 7 steps

1: toluene, reflux, 1 h

2: 25 percent / Raney-Ni / methanol / 23 h / reflux

3: 60 percent / pyridine, K₂CO₃ / Cu / 17 h / reflux

4: TsOH / benzene / 8 h / reflux

5: Na/liq.NH₃ / 3.5 h / -55 - -35 °C

6: 1n HCl / 1 h / reflux

7: 82 percent / pyridine hydrochloride / 5.5 h / 170 °C

With pyridine; hydrogenchloride; ammonia; pyridine hydrochloride; sodium; nickel; potassium carbonate; toluene-4-sulfonic acid; copper; In methanol; benzene;
DOI:10.1002/hlca.19900730212

Reference yield:

: 109026-99-5
17-(cyclopropylmethyl)-4,5α-epoxy-3,6α-dimethoxy-6β,14β-(2-phenyl-1-thiaethane-1,2-diyl)-morphinane

: 109026-86-0
14β-benzyl-17(cyclopropylmethyl)-3-hydroxymorphinan-6-one

Guidance literature:: Multi-step reaction with 6 steps

1: 25 percent / Raney-Ni / methanol / 23 h / reflux

2: 60 percent / pyridine, K₂CO₃ / Cu / 17 h / reflux

3: TsOH / benzene / 8 h / reflux

4: Na/liq.NH₃ / 3.5 h / -55 - -35 °C

5: 1n HCl / 1 h / reflux

6: 82 percent / pyridine hydrochloride / 5.5 h / 170 °C

With pyridine; hydrogenchloride; ammonia; pyridine hydrochloride; sodium; nickel; potassium carbonate; toluene-4-sulfonic acid; copper; In methanol; benzene;
DOI:10.1002/hlca.19900730212