4-(Cyclohexylmethyl)piperidine

Base Information

• Chemical Name: 4-(Cyclohexylmethyl)piperidine
• CAS No.: 78197-28-1
• Molecular Formula: C12H23N
• Molecular Weight: 181.321
• NSC Number: 173078
• UNII: VI7G0L7541
• DSSTox Substance ID: DTXSID50228833
• Nikkaji Number: J77.380H
• Wikidata: Q83108908
• Mol file: 78197-28-1.mol

Synonyms:4-(cyclohexylmethyl)piperidine;78197-28-1;Piperidine, 4-(cyclohexylmethyl)-;4-Cyclohexylmethylpiperidine;NSC 173078;BRN 0106768;VI7G0L7541;NSC-173078;NSC173078;UNII-VI7G0L7541;SCHEMBL2148995;DTXSID50228833;AC9848;MFCD01701069;AKOS011516037;SY262957;LS-114912;CS-0267547;FT-0752287;EN300-242135

Chemical Property of 4-(Cyclohexylmethyl)piperidine

Chemical Property:

• Vapor Pressure: 0.0141mmHg at 25°C
• Boiling Point: 258°Cat760mmHg
• Flash Point: 108.4°C
• Density: 0.895g/cm³
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 181.183049738
• Heavy Atom Count: 13
• Complexity: 132

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)CC2CCNCC2

Technology Process of 4-(Cyclohexylmethyl)piperidine

There total 3 articles about 4-(Cyclohexylmethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-benzylpyperidine (31252-42-3) → 4-Cyclohexylmethyl-piperidine (78197-28-1)

Guidance literature:

4-benzylpyperidine; With hydrogenchloride; hydrogen; platinum(IV) oxide; In 1,4-dioxane; ethanol; water; at 20 ℃; for 90h;

With sodium hydroxide; In diethyl ether; water; pH=12;

Reference yield:

4-benzyl pyridine (2116-65-6) → 4-Cyclohexylmethyl-piperidine (78197-28-1) + 4-benzylpyperidine (31252-42-3)

Guidance literature:

With hydrogenchloride; platinum; Hydrogenation;

Reference yield:

→ 4-Cyclohexylmethyl-piperidine (78197-28-1)

Guidance literature:

4-Benzyl-pyridin, H2, RuO2, 90-100grad, 100 atm., 2 Std.;

DOI:10.1021/jo01068a043

upstream raw materials:

4-benzyl pyridine

4-benzylpyperidine

Downstream raw materials:

3-(4-cyclohexylmethyl-piperidin-1-yl)-rifamycin

4'-(2-[4-cyclohexylmethylpiperidine-1-yl]ethoxy)-[1,1'-biphenyl]-4-ylcarboxylic acid

1-(2-Hydroxyethyl)-4-cyclohexylmethyl-piperidine

1-(3-[4-Cyclohexylmethyl-piperidin-1-yl]propyl)-1,3-dihydrobenzimidazol-2-one

Refernces