2-Furancarboxamide, N-[3-cyano-6-(4-fluoro-2-hydroxyphenyl)-4-[3-(1-piperazinylmethyl)phen yl]-2-pyridinyl]-, 2,2,2-trifluoroacetate (1:1)

Base Information

Chemical Name:2-Furancarboxamide, N-[3-cyano-6-(4-fluoro-2-hydroxyphenyl)-4-[3-(1-piperazinylmethyl)phen yl]-2-pyridinyl]-, 2,2,2-trifluoroacetate (1:1)
CAS No.:925930-19-4
Molecular Formula:C₂HF₃O₂*C₂₈H₂₄FN₅O₃
Molecular Weight:611.553
Hs Code.:

2-Furancarboxamide,
N-[3-cyano-6-(4-fluoro-2-hydroxyphenyl)-4-[3-(1-piperazinylmethyl)phen
yl]-2-pyridinyl]-, 2,2,2-trifluoroacetate (1:1)

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Furancarboxamide, N-[3-cyano-6-(4-fluoro-2-hydroxyphenyl)-4-[3-(1-piperazinylmethyl)phen yl]-2-pyridinyl]-, 2,2,2-trifluoroacetate (1:1)

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Technology Process of 2-Furancarboxamide, N-[3-cyano-6-(4-fluoro-2-hydroxyphenyl)-4-[3-(1-piperazinylmethyl)phen yl]-2-pyridinyl]-, 2,2,2-trifluoroacetate (1:1)

There total 1 articles about 2-Furancarboxamide, N-[3-cyano-6-(4-fluoro-2-hydroxyphenyl)-4-[3-(1-piperazinylmethyl)phen yl]-2-pyridinyl]-, 2,2,2-trifluoroacetate (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 925923-99-5
tert-butyl 4-(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}benzyl)piperazine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 925930-19-4
N-{3-cyano-6-(4-fluoro-2-hydroxyphenyl)-4-[3-(piperazin-1-ylmethyl)phenyl]pyridin-2-yl}furan-2-carboxamide trifluoroacetate

Guidance literature:: In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2010.05.061

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 925930-19-4
N-{3-cyano-6-(4-fluoro-2-hydroxyphenyl)-4-[3-(piperazin-1-ylmethyl)phenyl]pyridin-2-yl}furan-2-carboxamide trifluoroacetate

: 925981-54-0
N-[3-cyano-6-(4-fluoro-2-hydroxyphenyl)-4-{3-[(4-methylpiperazin-1-yl)methyl]phenyl}pyridin-2-yl]furan-2-carboxamide

Guidance literature:: formaldehyd; N-{3-cyano-6-(4-fluoro-2-hydroxyphenyl)-4-[3-(piperazin-1-ylmethyl)phenyl]pyridin-2-yl}furan-2-carboxamide trifluoroacetate; With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 4h;

With sodium hydrogencarbonate; In methanol; water;
DOI:10.1016/j.bmc.2010.05.061

Reference yield:

: 925930-19-4
N-{3-cyano-6-(4-fluoro-2-hydroxyphenyl)-4-[3-(piperazin-1-ylmethyl)phenyl]pyridin-2-yl}furan-2-carboxamide trifluoroacetate

: 75-07-0,9002-91-9
acetaldehyde

: 925981-55-1
N-[3-cyano-4-{3-[(4-ethylpiperazin-1-yl)methyl]phenyl}-6-(4-fluoro-2-hydroxyphenyl)pyridin-2-yl]furan-2-carboxamide

Guidance literature:: N-{3-cyano-6-(4-fluoro-2-hydroxyphenyl)-4-[3-(piperazin-1-ylmethyl)phenyl]pyridin-2-yl}furan-2-carboxamide trifluoroacetate; acetaldehyde; With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 4h;

With sodium hydrogencarbonate; In methanol; water;
DOI:10.1016/j.bmc.2010.05.061