8-((3,5-Dimethyl-1H-pyrazol-1-yl)methyl)-6-methylergoline (8-beta)-

Base Information

• Chemical Name: 8-((3,5-Dimethyl-1H-pyrazol-1-yl)methyl)-6-methylergoline (8-beta)-
• CAS No.: 105579-46-2
• Molecular Formula: C₂₁H₂₆N₄
• Molecular Weight: 334.464
• DSSTox Substance ID: DTXSID80909603
• Mol file: 105579-46-2.mol

Synonyms:8-((3,5-Dimethyl-1H-pyrazol-1-yl)methyl)-6-methylergoline (8-beta)-;Ergoline, 8-((3,5-dimethyl-1H-pyrazol-1-yl)methyl)-6-methyl-, (8-beta)-;105579-46-2;SCHEMBL10755633;DTXSID80909603;C21H26N4;LS-64413;8-[(3,5-Dimethyl-1H-pyrazol-1-yl)methyl]-6-methylergoline

Chemical Property of 8-((3,5-Dimethyl-1H-pyrazol-1-yl)methyl)-6-methylergoline (8-beta)-

Chemical Property:

• Vapor Pressure: 2.28E-11mmHg at 25°C
• Boiling Point: 531.3°Cat760mmHg
• Flash Point: 275.1°C
• Density: 1.3g/cm³
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 334.21574685
• Heavy Atom Count: 25
• Complexity: 496

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NN1CC2CC3C(CC4=CNC5=CC=CC3=C45)N(C2)C)C
• Isomeric SMILES: CC1=CC(=NN1C[C@@H]2CC3[C@@H](CC4=CNC5=CC=CC3=C45)N(C2)C)C

Technology Process of 8-((3,5-Dimethyl-1H-pyrazol-1-yl)methyl)-6-methylergoline (8-beta)-

There total 5 articles about 8-((3,5-Dimethyl-1H-pyrazol-1-yl)methyl)-6-methylergoline (8-beta)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9,10-dihydrolysergic acid (5878-43-3) → 3,5-Dimethyl-1-(6-methylergolin-8β-ylmethyl)pyrazole (105579-46-2)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂SO₄

2: 82 percent / aq. NaBH₄ / methanol / 2 h / Heating

3: 80 percent / pyridine / 3 h / Ambient temperature

4: 1.) NaH / 1.) DMF, 2.) DMF, 90 deg C, 2 h

With pyridine; sodium tetrahydroborate; sulfuric acid; sodium hydride; In methanol;

DOI:10.1248/cpb.42.1463

Reference yield:

9,10-dihydrolysergic acid methyl ester (3006-19-7,5143-94-2,35470-53-2,77842-02-5,87247-99-2,96648-31-6,96648-32-7) → 3,5-Dimethyl-1-(6-methylergolin-8β-ylmethyl)pyrazole (105579-46-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / aq. NaBH₄ / methanol / 2 h / Heating

2: 80 percent / pyridine / 3 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 2.) DMF, 90 deg C, 2 h

With pyridine; sodium tetrahydroborate; sodium hydride; In methanol;

DOI:10.1248/cpb.42.1463

Reference yield:

9,10-dihydrolysergol (18051-16-6,1349-51-5) → 3,5-Dimethyl-1-(6-methylergolin-8β-ylmethyl)pyrazole (105579-46-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / pyridine / 3 h / Ambient temperature

2: 1.) NaH / 1.) DMF, 2.) DMF, 90 deg C, 2 h

With pyridine; sodium hydride;

DOI:10.1248/cpb.42.1463

upstream raw materials:

3,5-dimethyl-1H-pyrazole

6-methyl-8β-tosyloxymethyl-ergoline

9,10-dihydrolysergol

9,10-dihydrolysergic acid