Technology Process of 2-Propenamide,
3-[1-[(2,4-dichlorophenyl)methyl]-3-(1-methylethoxy)-1H-pyrazol-5-yl]-N-
(pentylsulfonyl)-, (2E)-
There total 10 articles about 2-Propenamide,
3-[1-[(2,4-dichlorophenyl)methyl]-3-(1-methylethoxy)-1H-pyrazol-5-yl]-N-
(pentylsulfonyl)-, (2E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E)-3-[1-(2,4-dichlorobenzyl)-3-isopropoxy-1H-pyrazol-5-yl]propenoic acid;
With
1,1'-carbonyldiimidazole;
In
N,N-dimethyl-formamide;
at 20 ℃;
1-pentylsulfonamide;
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
N,N-dimethyl-formamide;
at 100 ℃;
DOI:10.1016/j.bmc.2011.12.008
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: methanol / 2 h / Reflux
1.2: 1 h / Reflux
2.1: potassium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 20 °C / Cooling with ice
3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0 - 20 °C
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C
4.2: -78 - 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
5.2: 0 - 20 °C
6.1: hydrogenchloride / ethanol; water / Reflux
7.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
8.1: sodium hydroxide / tetrahydrofuran; methanol / 50 °C
9.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 20 °C
9.2: 100 °C
With
hydrogenchloride; oxalyl dichloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; 1,1'-carbonyldiimidazole; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
1.1: Michael addition / 4.1: Swern oxidation / 4.2: Swern oxidation / 5.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.bmc.2011.12.008
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 20 °C / Cooling with ice
2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0 - 20 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C
3.2: -78 - 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
4.2: 0 - 20 °C
5.1: hydrogenchloride / ethanol; water / Reflux
6.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
7.1: sodium hydroxide / tetrahydrofuran; methanol / 50 °C
8.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 20 °C
8.2: 100 °C
With
hydrogenchloride; oxalyl dichloride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; 1,1'-carbonyldiimidazole; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
3.1: Swern oxidation / 3.2: Swern oxidation / 4.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.bmc.2011.12.008
![(E)-3-[1-(2,4-dichlorobenzyl)-3-isopropoxy-1H-pyrazol-5-yl]propenoic acid](/Databaselist/images/loading.webp)
