2-[[(1S)-1-[2,4,6-Tris(1-methylethyl)phenyl]ethyl]amino]acetonitrile

Base Information

Chemical Name:2-[[(1S)-1-[2,4,6-Tris(1-methylethyl)phenyl]ethyl]amino]acetonitrile
CAS No.:926622-54-0
Molecular Formula:C19H30N2
Molecular Weight:286.461
Hs Code.:
DSSTox Substance ID:DTXSID601159701

Synonyms:DTXSID601159701;2-[[(1S)-1-[2,4,6-Tris(1-methylethyl)phenyl]ethyl]amino]acetonitrile;926622-54-0

Suppliers and Price of 2-[[(1S)-1-[2,4,6-Tris(1-methylethyl)phenyl]ethyl]amino]acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[[(1S)-1-[2,4,6-Tris(1-methylethyl)phenyl]ethyl]amino]acetonitrile

Chemical Property:

XLogP3:4.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:286.240898965
Heavy Atom Count:21
Complexity:332

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)C1=CC(=C(C(=C1)C(C)C)C(C)NCC#N)C(C)C
Isomeric SMILES:C[C@@H](C1=C(C=C(C=C1C(C)C)C(C)C)C(C)C)NCC#N

Technology Process of 2-[[(1S)-1-[2,4,6-Tris(1-methylethyl)phenyl]ethyl]amino]acetonitrile

There total 5 articles about 2-[[(1S)-1-[2,4,6-Tris(1-methylethyl)phenyl]ethyl]amino]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 926622-53-9
(S)-1-(2,4,6-triisopropylphenyl)ethylamine

: 624-75-9
iodoacetonitrile

: 926622-54-0
(S)-[1-(2,4,6-triisopropylphenyl)ethylamino]acetonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1021/jo061976i

Reference yield:

: 926622-60-8
2-(1-azido-ethyl)-1,3,5-triisopropyl-benzene

: 926622-54-0
(S)-[1-(2,4,6-triisopropylphenyl)ethylamino]acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium on carbon / ethanol / 64 h

2: 16.03 g / pyridine / CH₂Cl₂ / 13 h / 20 °C

3: 90 percent / KOH / ethane-1,2-diol / Heating

4: 91 percent / potassium carbonate / dimethylformamide / 5 h / 20 °C

With pyridine; potassium hydroxide; hydrogen; potassium carbonate; palladium on activated charcoal; In ethanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;
DOI:10.1021/jo061976i

Reference yield:

: 102225-88-7,24226-23-1
(+/-)-1-(2,4,6-triisopropylphenyl)ethanol

: 926622-54-0
(S)-[1-(2,4,6-triisopropylphenyl)ethylamino]acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; Zn(N₃)2(pyridine)2; diisopropyl azodicarboxylate / toluene / 48 h / 20 °C

2: hydrogen / palladium on carbon / ethanol / 64 h

3: 16.03 g / pyridine / CH₂Cl₂ / 13 h / 20 °C

4: 90 percent / KOH / ethane-1,2-diol / Heating

5: 91 percent / potassium carbonate / dimethylformamide / 5 h / 20 °C

With pyridine; potassium hydroxide; Zn(N₃)2/bis-pyridine complex; di-isopropyl azodicarboxylate; hydrogen; potassium carbonate; triphenylphosphine; palladium on activated charcoal; In ethanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo061976i