6-Morpholin-4-Yl-9h-Purine

Base Information

• Chemical Name: 6-Morpholin-4-Yl-9h-Purine
• CAS No.: 2846-96-0
• Molecular Formula: C9H11 N5 O
• Molecular Weight: 205.219
• Hs Code.: 2934999090
• European Community (EC) Number: 220-645-3
• NSC Number: 351559
• UNII: 89VN5RQ48X
• DSSTox Substance ID: DTXSID80182656
• Nikkaji Number: J306.774B
• Wikidata: Q27097960
• Metabolomics Workbench ID: 151895
• ChEMBL ID: CHEMBL271138
• Mol file: 2846-96-0.mol

Synonyms:2846-96-0;6-(morpholin-4-yl)-9H-purine;6-Morpholin-4-Yl-9h-Purine;4-(1H-Purin-6-yl)morpholine;6-Morpholinopurine;4-(7H-purin-6-yl)morpholine;4-(9h-purin-6-yl)morpholine;9H-Purine, 6-(4-morpholinyl)-;MFCD00496816;EINECS 220-645-3;NSC-351559;C9H11N5O;SMR000017638;MLS000080575;2wmu;6-Morpholinopurine`;6-morpholino-9H-purine;6-Morpholino-1H-purine;D0S3TJ;Oprea1_261650;Oprea1_519977;MLS000104086;SCHEMBL336612;89VN5RQ48X;CHEMBL271138;BDBM33210;DTXSID80182656;HMS2298A04;HMS3604M21;CAA84696;NSC351559;STK055616;AKOS001427795;CCG-253685;DB08780;NSC 351559;6-(MORPHOLIN-4-YL)-1H-PURINE;6-(Morpholin-4-yl)-9H-purine, 95%;BS-49897;CS-0216869;EN300-63842;E78057;A918435;SR-01000398535;SR-01000398535-1;Q27097960;Z57921676;ZYU

Chemical Property of 6-Morpholin-4-Yl-9h-Purine

Chemical Property:

• Boiling Point: 527.1°Cat760mmHg
• Flash Point: 272.6°C
• PSA: 66.93000
• Density: 1.416g/cm³
• LogP: 0.25450
• Storage Temp.: 2-8°C
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 205.09635999
• Heavy Atom Count: 15
• Complexity: 221

Purity/Quality:

97% ^*data from raw suppliers

4-(1H-Purin-6-yl)morpholine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=NC=NC3=C2NC=N3

Technology Process of 6-Morpholin-4-Yl-9h-Purine

There total 18 articles about 6-Morpholin-4-Yl-9h-Purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + 6-chloropurine (87-42-3) → 6-morpholinopurine (2846-96-0)

Guidance literature:

With indium(III) chloride; In acetonitrile; at 120 ℃; for 0.5h; regioselective reaction; Microwave irradiation;

DOI:10.1002/adsc.201400674

Reference yield: 95.0%

morpholine (110-91-8,99108-56-2) + 6-chloro-7H-purine (87-42-3,111055-92-6) → 6-morpholinopurine (2846-96-0)

Guidance literature:

at 80 ℃;

DOI:10.1016/j.bmcl.2018.03.046

Reference yield: 65.0%

morpholine (110-91-8,99108-56-2) + 5-amino-4-(cyanoformimidoyl)-1H-imidazole (81693-59-6) → 6-morpholinopurine (2846-96-0)

Guidance literature:

at 20 ℃; for 1.5h;

DOI:10.1002/ejoc.200700416

upstream raw materials:

2-chloro-6-morpholin-4-yl-7⁽⁹⁾H-purine

6-morpholino-5-nitropyrimidin-4-amine

2,8-dichloro-6-morpholin-4-yl-7⁽⁹⁾H-purine

morpholine