1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-(1-methylethyl)-, 1,1-dimethylethyl ester, (2S,4R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-(1-methylethyl)-, 1,1-dimethylethyl ester, (2S,4R)-
CAS No.:927893-02-5
Molecular Formula:C12H23NO3
Molecular Weight:229.32
Hs Code.:

Synonyms:

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-(1-methylethyl)-, 1,1-dimethylethyl ester, (2S,4R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-(1-methylethyl)-, 1,1-dimethylethyl ester, (2S,4R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-(1-methylethyl)-, 1,1-dimethylethyl ester, (2S,4R)-

There total 1 articles about 1-Pyrrolidinecarboxylic acid, 4-hydroxy-2-(1-methylethyl)-, 1,1-dimethylethyl ester, (2S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 927893-02-5
tert-butyl (2S,4R)-4-hydroxy-2-(propan-2-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 20 °C / Large scale

1.2: 0 - 20 °C / Large scale

2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3.1: magnesium / diethyl ether / 30 °C / Reflux

3.2: 4 h / 0 - 20 °C

4.1: triethylamine / toluene / 0.17 h / -78 °C

4.2: 3.5 h / -78 °C

5.1: hydrogen / methanol / 3 h / 60 °C / 30402 Torr

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; hydrogen; magnesium; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 927893-02-5
tert-butyl (2S,4R)-4-hydroxy-2-(propan-2-yl)pyrrolidine-1-carboxylate

: 1616429-62-9
3-{4-(5-chloropyridin-3-yl)-2-[(2S,4R)-4-methoxy-2-(1-methylethyl)pyrrolidin-1-yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridin-6-yl}-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; potassium fluoride / dimethyl sulfoxide / 16 h / 100 °C / Sealed tube

3: sodium hydride / tetrahydrofuran / 3 h / 0 - 20 °C

4: hydroxylamine hydrochloride; sodium hydrogencarbonate / water; ethanol / 1 h / 100 °C

5: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 1 h / 20 °C

With potassium fluoride; hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 927893-02-5
tert-butyl (2S,4R)-4-hydroxy-2-(propan-2-yl)pyrrolidine-1-carboxylate

: 1616435-05-2
4-(5-chloropyridin-3-yl)-2-[(2S,4R)-4-hydroxy-2-(propan-2-yl)pyrrolidin-1-yl]-3-[(trans-4-methylcyclohexyl)methyl]-3H-imidazo[4,5-c]pyridine-6-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; potassium fluoride / dimethyl sulfoxide / 16 h / 100 °C / Sealed tube

With potassium fluoride; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide;