2-(2-(cis-3-(Piperidin-1-yl)cyclobutyl)benzothiazol-6-yl)pyridazin-3(2H)-one

Base Information

Chemical Name:2-(2-(cis-3-(Piperidin-1-yl)cyclobutyl)benzothiazol-6-yl)pyridazin-3(2H)-one
CAS No.:929608-13-9
Molecular Formula:C₂₀H₂₂N₄OS
Molecular Weight:366.487
Hs Code.:
Mol file:929608-13-9.mol

Synonyms:2-(2-(cis-3-(Piperidin-1-yl)cyclobutyl)benzothiazol-6-yl)pyridazin-3(2H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-(cis-3-(Piperidin-1-yl)cyclobutyl)benzothiazol-6-yl)pyridazin-3(2H)-one

Chemical Property:

PSA：79.26000
LogP:3.51200

Purity/Quality:

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Technology Process of 2-(2-(cis-3-(Piperidin-1-yl)cyclobutyl)benzothiazol-6-yl)pyridazin-3(2H)-one

There total 17 articles about 2-(2-(cis-3-(Piperidin-1-yl)cyclobutyl)benzothiazol-6-yl)pyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 110-89-4
piperidine

: 929608-15-1
2-(2-(3-oxocyclobutyl)benzothiazol-6-yl)pyridazin-3(2H)-one

: 929608-13-9
2-(2-(cis-3-(piperidin-1-yl)cyclobutyl)benzothiazol-6-yl)pyridazin-3(2H)-one

Guidance literature:: With sodium tri(pivaloyloxy)borohydride; In toluene; at 5 ℃; for 16h; Solvent; Temperature; Reagent/catalyst; diastereoselective reaction; Inert atmosphere; Large scale;
DOI:10.1021/op3002883

Reference yield:

: 110-89-4
piperidine

: 929608-13-9
trans-2-[2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazol-6-yl]pyridazin-3(2H)-one

Guidance literature:: cis-2-[2-(3-hydroxy-cyclobutyl)-1,3-benzothiazol-6-yl]-2H-pyridazin-3-one; With potassium carbonate; trifluoromethanesulfonic acid anhydride; In dichloromethane; at 20 - 30 ℃; for 2h;

piperidine; With potassium carbonate; In dichloromethane; at 20 - 30 ℃; Product distribution / selectivity;

Reference yield:

: 110-89-4
piperidine

: 929608-15-1
2-(2-(3-oxocyclobutyl)benzothiazol-6-yl)pyridazin-3(2H)-one

: 929608-13-9
cis-2-[2-(3-piperidin-1-ylcyclobutyl)-1,3-benzothiazol-6-yl]pyridazin-3(2H)-one

Guidance literature:: piperidine; 2-(2-(3-oxocyclobutyl)benzothiazol-6-yl)pyridazin-3(2H)-one; In methanol; at 20 - 30 ℃; for 1h;

With sodium cyanoborohydride; In methanol; at 20 - 30 ℃;

With water; In methanol; Product distribution / selectivity;