2H-Pyran-2-one, 6-[(1E)-2-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]tetra hydro-4-hydroxy-, (4R,6S)-rel-

Base Information

• Chemical Name: 2H-Pyran-2-one, 6-[(1E)-2-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]tetra hydro-4-hydroxy-, (4R,6S)-rel-
• CAS No.: 93957-56-3
• Molecular Formula: C₂₄H₂₄FNO₃
• Molecular Weight: 393.458
• Mol file: 93957-56-3.mol

Synonyms:

Chemical Property of 2H-Pyran-2-one, 6-[(1E)-2-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]tetra hydro-4-hydroxy-, (4R,6S)-rel-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Pyran-2-one, 6-[(1E)-2-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]tetra hydro-4-hydroxy-, (4R,6S)-rel-

There total 1 articles about 2H-Pyran-2-one, 6-[(1E)-2-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]tetra hydro-4-hydroxy-, (4R,6S)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

fluvastatin sodium → trans-6-<2-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one (93957-56-3,93957-57-4,94061-83-3,141109-99-1)

Guidance literature:

fluvastatin sodium; With hydrogenchloride; In water; ethyl acetate; at 20 ℃; Darkness; Cooling with ice;

With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h; Darkness; Cooling with ice;

Reference yield: 92.0%

trans-6-<2-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one (93957-56-3,93957-57-4,94061-83-3,141109-99-1) → racemic (3R,5S,E)-7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-N,3,5-trihydroxyhept-6-enamide

Guidance literature:

With hydroxylamine; In tetrahydrofuran; water; for 24h;

Reference yield: 91.0%

cis-6-<2-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one (93957-56-3,93957-57-4,94061-83-3,141109-99-1) → cis-6-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>-3,6-dihydro-2H-pyran-2-acetic acid (109856-13-5)

Guidance literature:

With hydrogenchloride; In acetonitrile; at 20 ℃; for 3h;

Downstream raw materials:

cis-6-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>-3,6-dihydro-2H-pyran-2-acetic acid

7-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>-2,4,6-heptatrienoic acid