4-(3,7-Dimethylimidazo[1,2-a]pyridin-2-yl)-2-nitrophenol

Base Information

Chemical Name:4-(3,7-Dimethylimidazo[1,2-a]pyridin-2-yl)-2-nitrophenol
CAS No.:94662-28-9
Molecular Formula:C15H13N3O3
Molecular Weight:283.287
Hs Code.:
DSSTox Substance ID:DTXSID30552522
Wikidata:Q82432832

Synonyms:94662-28-9;SCHEMBL10653410;DTXSID30552522;FYBUGLDJURUPSV-UHFFFAOYSA-N;4-(3,7-Dimethylimidazo[1,2-a]pyridin-2-yl)-2-nitrophenol;3,7-dimethyl-2-(4-hydroxy-3-nitrophenyl)imidazo[1,2-a]pyridine

Suppliers and Price of 4-(3,7-Dimethylimidazo[1,2-a]pyridin-2-yl)-2-nitrophenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-(3,7-Dimethylimidazo[1,2-a]pyridin-2-yl)-2-nitrophenol

Chemical Property:

PSA：83.35000
LogP:3.75510
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:283.09569129
Heavy Atom Count:21
Complexity:400

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=NC(=C(N2C=C1)C)C3=CC(=C(C=C3)O)[N+](=O)[O-]

Technology Process of 4-(3,7-Dimethylimidazo[1,2-a]pyridin-2-yl)-2-nitrophenol

There total 2 articles about 4-(3,7-Dimethylimidazo[1,2-a]pyridin-2-yl)-2-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.9%

: 695-34-1
2-Amino-4-methylpyridine

: 139416-95-8
2-Bromo-4'-hydroxy-3'-nitropropiophenone

: 94662-28-9
3,7-Dimethyl-2-(4-hydroxy-3-nitrophenyl)imidazo<1,2-a>pyridine

Guidance literature:: With triethylamine; In tetrahydrofuran; 1.) r.t., 2.) 60-70 deg C;
DOI:10.1248/cpb.39.2937

Reference yield:

: 50916-44-4
1-(4-hydroxy-3-nitrophenyl)propan-1-one

: 94662-28-9
3,7-Dimethyl-2-(4-hydroxy-3-nitrophenyl)imidazo<1,2-a>pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 94.1 percent / pyridinium bromide perbromide, 30 percent HBr-AcOH / acetic acid / 1 h / Ambient temperature

2: 35.9 percent / Et₃N / tetrahydrofuran / 1.) r.t., 2.) 60-70 deg C

With hydrogen bromide; pyridinium hydrobromide perbromide; acetic acid; triethylamine; In tetrahydrofuran; acetic acid;
DOI:10.1248/cpb.39.2937

Reference yield: 82.0%

: 94662-28-9
3,7-Dimethyl-2-(4-hydroxy-3-nitrophenyl)imidazo<1,2-a>pyridine

: 141244-40-8
2-Amino-4-(3,7-dimethyl-5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl)-phenol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 60 - 70 ℃; for 3h; under 2280 - 3800 Torr;
DOI:10.1248/cpb.40.371