1,5-dihydro-7-(1-piperidinyl)-imidazo(2,1-b)quinazolin-2(3H)-one

Base Information

Chemical Name:1,5-dihydro-7-(1-piperidinyl)-imidazo(2,1-b)quinazolin-2(3H)-one
CAS No.:96086-67-8
Molecular Formula:C₁₅H₁₈N₄O
Molecular Weight:270.334
Hs Code.:
Mol file:96086-67-8.mol

Synonyms:1,5-DIHYDRO-7-(1-PIPERIDINYL)-IMIDAZO-(2,1-BETA)QUINAZOLIN-2-(3H)-ONE;7-piperidino-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-one;

Suppliers and Price of 1,5-dihydro-7-(1-piperidinyl)-imidazo(2,1-b)quinazolin-2(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 1,5-dihydro-7-(1-piperidinyl)-imidazo(2,1-b)quinazolin-2(3H)-one

Chemical Property:

Vapor Pressure:1.34E-08mmHg at 25°C
PSA：47.94000
LogP:1.37710

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,5-dihydro-7-(1-piperidinyl)-imidazo(2,1-b)quinazolin-2(3H)-one

There total 9 articles about 1,5-dihydro-7-(1-piperidinyl)-imidazo(2,1-b)quinazolin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96086-66-7
ethyl 2-chloro-6-piperidino-3,4-dihydro-3-quinazolineacetate

: 96086-67-8
7-piperidino-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-2-one

Guidance literature:: With ammonia; In ethanol; at 120 - 130 ℃; for 4h; Yield given;
DOI:10.1021/jm00148a003

Reference yield:

: 110-89-4
piperidine

: 96086-67-8
7-piperidino-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / dimethylformamide / 0.5 h / 50 °C

2: 74 percent / conc. aq. HCl, SnCl₂*2H₂O / 2 h / Ambient temperature

3: 2.5 h / 180 - 210 °C

4: 66 percent / phosphoryl chloride, N,N-diisopropylethylamine / 18 h / Heating

5: NaBH₄ / CHCl₃; ethanol / 0.5 h

6: 10M aq. NaOH, tetrabutylammonium iodide / CH₂Cl₂ / 1 h

7: NH₃ / ethanol / 4 h / 120 - 130 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; ammonia; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; trichlorophosphate; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00148a003

Reference yield:

: 13514-93-7
2-amino-5-piperidinobenzonitrile

: 96086-67-8
7-piperidino-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 2.5 h / 180 - 210 °C

2: 66 percent / phosphoryl chloride, N,N-diisopropylethylamine / 18 h / Heating

3: NaBH₄ / CHCl₃; ethanol / 0.5 h

4: 10M aq. NaOH, tetrabutylammonium iodide / CH₂Cl₂ / 1 h

5: NH₃ / ethanol / 4 h / 120 - 130 °C

With sodium hydroxide; sodium tetrahydroborate; ammonia; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In ethanol; dichloromethane; chloroform;
DOI:10.1021/jm00148a003