diphenylmethyl (4S,7S,12bR)-7-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-6-oxo-1,2,3,4,6,7,8,12b-octahydropyrido[2,1-a][2]benzazepine-4-carboxylate

Base Information

Chemical Name:diphenylmethyl (4S,7S,12bR)-7-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-6-oxo-1,2,3,4,6,7,8,12b-octahydropyrido[2,1-a][2]benzazepine-4-carboxylate
CAS No.:111581-91-0
Molecular Formula:C40H42 N2 O5
Molecular Weight:630.7719
Hs Code.:
Mol file:111581-91-0.mol

diphenylmethyl (4S,7S,12bR)-7-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-6-oxo-1,2,3,4,6,7,8,12b-octahydropyrido[2,1-a][2]benzazepine-4-carboxylate

Synonyms:Pyrido[2,1-a][2]benzazepine-4-carboxylicacid,7-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1,2,3,4,6,7,8,12b-octahydro-6-oxo-,diphenylmethyl ester, [4S-[4a,7a(R*),12bb]]-; MDL 27467A

Suppliers and Price of diphenylmethyl (4S,7S,12bR)-7-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-6-oxo-1,2,3,4,6,7,8,12b-octahydropyrido[2,1-a][2]benzazepine-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of diphenylmethyl (4S,7S,12bR)-7-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-6-oxo-1,2,3,4,6,7,8,12b-octahydropyrido[2,1-a][2]benzazepine-4-carboxylate

Chemical Property:

Vapor Pressure:2.03E-24mmHg at 25°C
Boiling Point:782.2°Cat760mmHg
Flash Point:426.8°C
Density:1.24g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of diphenylmethyl (4S,7S,12bR)-7-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-6-oxo-1,2,3,4,6,7,8,12b-octahydropyrido[2,1-a][2]benzazepine-4-carboxylate

There total 4 articles about diphenylmethyl (4S,7S,12bR)-7-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-6-oxo-1,2,3,4,6,7,8,12b-octahydropyrido[2,1-a][2]benzazepine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: (R)-4-Phenyl-2-(2,2,2-trifluoro-acetoxy)-butyric acid ethyl ester

: 111581-90-9
(4S,7S,12bR)-7-Amino-6-oxo-1,2,3,4,6,7,8,12b-octahydro-benzo[c]pyrido[1,2-a]azepine-4-carboxylic acid benzhydryl ester

: 111581-91-0
(4S,7S,12bR)-7-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-6-oxo-1,2,3,4,6,7,8,12b-octahydro-benzo[c]pyrido[1,2-a]azepine-4-carboxylic acid benzhydryl ester

Guidance literature:: With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In dichloromethane;
DOI:10.1021/ja00259a068

Reference yield:

: 116330-65-5
(4S,7S,12bR)-7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-6-oxo-1,2,3,4,6,7,8,12b-octahydro-benzo[c]pyrido[1,2-a]azepine-4-carboxylic acid methyl ester

: 111581-91-0
(4S,7S,12bR)-7-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-6-oxo-1,2,3,4,6,7,8,12b-octahydro-benzo[c]pyrido[1,2-a]azepine-4-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂

2: NH₂NH₂ / methanol / Heating

3: 88 percent / 1,8-bis(dimethylamino)naphthalene / CH₂Cl₂

With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; hydrazine; In methanol; dichloromethane;
DOI:10.1021/ja00259a068

Reference yield:

: 111581-89-6
(4S,7S,12bR)-7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-6-oxo-1,2,3,4,6,7,8,12b-octahydro-benzo[c]pyrido[1,2-a]azepine-4-carboxylic acid benzhydryl ester

: 111581-91-0
(4S,7S,12bR)-7-((S)-1-Ethoxycarbonyl-3-phenyl-propylamino)-6-oxo-1,2,3,4,6,7,8,12b-octahydro-benzo[c]pyrido[1,2-a]azepine-4-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NH₂NH₂ / methanol / Heating

2: 88 percent / 1,8-bis(dimethylamino)naphthalene / CH₂Cl₂

With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; hydrazine; In methanol; dichloromethane;
DOI:10.1021/ja00259a068