Amn082 dihydrochloride

Base Information

• Chemical Name: Amn082 dihydrochloride
• CAS No.: 97075-46-2
• Molecular Formula: C28H28N2.2ClH
• Molecular Weight: 465.45700
• European Community (EC) Number: 635-533-3
• ChEMBL ID: CHEMBL1613220
• DSSTox Substance ID: DTXSID701017562
• Wikidata: Q4652677
• Wikipedia: AMN082
• Mol file: 97075-46-2.mol

Synonyms:AMN082;N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride

Chemical Property of Amn082 dihydrochloride

Chemical Property:

• PSA: 24.06000
• LogP: 8.13060
• Storage Temp.: ?20°C
• Solubility.: <46.55mg/ml in DMSO;insoluble in H2O
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 9
• Exact Mass: 464.1786044
• Heavy Atom Count: 32
• Complexity: 362

Purity/Quality:

97% ^*data from raw suppliers

AMN082Dihydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn,N
• Statements: 22-50
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)NCCNC(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl
• Description: AMN082 is an orally bioavailable allosteric agonist of metabotropic glutamate receptor 7 (mGluR7). It inhibits cAMP accumulation induced by forskolin in CHO cells expressing human mGluR7b (EC50 = 64 nM). AMN082 (10 μM) is selective for mGluR7a and mGluR7b over mGluR1b, mGluR4, and mGluR8a with 140, 90, 15, 18, and 20% activation, respectively, as well as over mGluR2, mGluR3, mGluR5a, mGluR6, GluR3, and NMDA receptors containing NR1a, NR2A, or NR2B subunits. AMN082 also binds to the norepinephrine transporter (NET) and α1-adrenergic receptor (α1-AR). It increases the proliferation of neural progenitor cells (NPCs) and induces their differentiation into neurons when used at a concentration of 1 μM. AMN082 (2.5 mg/kg) inhibits apomorphine-induced circling in a rat model of Parkinson''s disease induced by 6-hydroxy dopamine (6-OHDA; ).