7-Bromo-1,5-naphthyridin-4-ol

Base Information

• Chemical Name: 7-Bromo-1,5-naphthyridin-4-ol
• CAS No.: 97267-60-2
• Molecular Formula: C8H5BrN2O
• Molecular Weight: 225.04200
• DSSTox Substance ID: DTXSID101308349
• Mol file: 97267-60-2.mol

Synonyms:7-bromo-1,5-naphthyridin-4-ol;97267-60-2;7-bromo-1,5-Naphthyridin-4(1H)-one;1151802-14-0;7-bromo-1H-1,5-naphthyridin-4-one;SCHEMBL1141394;7-bromo[1,5]naphthyridin-4-ol;XYJDSGQWBGLNRG-UHFFFAOYSA-N;DTXSID101308349;7-Bromo-[1,5]naphthyridin-4-ol;AMY26385;XDA26760;MFCD22571057;AKOS022655334;7-Bromo-1H-[1,5]naphthyridin-4-one;AS-49678;G10479;K10095

Chemical Property of 7-Bromo-1,5-naphthyridin-4-ol

Chemical Property:

• Melting Point: >360 °C (decomp)
• Boiling Point: 365.9±37.0 °C (760 mmHg)
• PKA: 2.32±0.40(Predicted)
• PSA: 46.01000
• Density: 1.805±0.06 g/cm3(20 °C , 760mmHg)
• LogP: 2.09790
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 223.95853
• Heavy Atom Count: 12
• Complexity: 229

Purity/Quality:

97% ^*data from raw suppliers

7-Bromo-1,5-naphthyridin-4-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CNC2=C(C1=O)N=CC(=C2)Br

Technology Process of 7-Bromo-1,5-naphthyridin-4-ol

There total 10 articles about 7-Bromo-1,5-naphthyridin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

5-{[(5-bromopyridin-3-yl)amino]methylidene}-2,2-dimethyl-1,3-dioxane-4,6-dione (1151802-13-9) → 7-bromo-1,5-naphthyridin-4-ol (97267-60-2)

Guidance literature:

With Dowtherm A; at 235 - 240 ℃; for 0.166667h;

DOI:10.1002/cmdc.201300384

Reference yield:

5-{[(5-bromopyridin-3-yl)imino]methyl}-2,2-dimethyl-1,3-dioxane-4,6-dione (847436-88-8) → 7-bromo-1,5-naphthyridin-4-ol (97267-60-2)

Guidance literature:

In diphenyl ether-biphenyl eutectic; at 235 - 238 ℃; for 0.166667h;

Reference yield:

7-bromo-4-hydroxy-1,5-naphthyridine-3-carboxylic acid (97267-59-9) → 7-bromo-1,5-naphthyridin-4-ol (97267-60-2)

Guidance literature:

With quinoline; for 1h; Heating;

DOI:10.1071/CH9850459

upstream raw materials:

7-bromo-4-hydroxy-1,5-naphthyridine-3-carboxylic acid

ethyl 7-bromo-4-hydroxy-1,5-naphthyridine-3-carboxylate

5-{[(5-bromopyridin-3-yl)imino]methyl}-2,2-dimethyl-1,3-dioxane-4,6-dione

5-bromonicotinamide

Downstream raw materials:

1-(7-bromo-1,5-naphthyridin-4-yl)-3-cyclohexylurea

1-(7-bromo-1,5-naphthyridin-4-yl)-3-phenylurea

1-benzyl-3-(7-bromo-1,5-naphthyridin-4-yl)urea

1-(7-bromo-1,5-naphthyridin-4-yl)-3-(2-phenylethyl)urea