1H-Pyrrole-2-carboxylic acid, 5-[[5-(2-cyano-3-methoxy-3-oxo-1-propenyl)-3-ethyl-4-methyl-1H-pyrrol- 2-yl]methyl]-4-ethyl-3-methyl-, phenylmethyl ester

Base Information

Chemical Name:1H-Pyrrole-2-carboxylic acid, 5-[[5-(2-cyano-3-methoxy-3-oxo-1-propenyl)-3-ethyl-4-methyl-1H-pyrrol- 2-yl]methyl]-4-ethyl-3-methyl-, phenylmethyl ester
CAS No.:97336-24-8
Molecular Formula:C₂₈H₃₁N₃O₄
Molecular Weight:473.572
Hs Code.:

1H-Pyrrole-2-carboxylic acid,
5-[[5-(2-cyano-3-methoxy-3-oxo-1-propenyl)-3-ethyl-4-methyl-1H-pyrrol-
2-yl]methyl]-4-ethyl-3-methyl-, phenylmethyl ester

Synonyms:

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Chemical Property of 1H-Pyrrole-2-carboxylic acid, 5-[[5-(2-cyano-3-methoxy-3-oxo-1-propenyl)-3-ethyl-4-methyl-1H-pyrrol- 2-yl]methyl]-4-ethyl-3-methyl-, phenylmethyl ester

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-2-carboxylic acid, 5-[[5-(2-cyano-3-methoxy-3-oxo-1-propenyl)-3-ethyl-4-methyl-1H-pyrrol- 2-yl]methyl]-4-ethyl-3-methyl-, phenylmethyl ester

There total 12 articles about 1H-Pyrrole-2-carboxylic acid, 5-[[5-(2-cyano-3-methoxy-3-oxo-1-propenyl)-3-ethyl-4-methyl-1H-pyrrol- 2-yl]methyl]-4-ethyl-3-methyl-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.1%

: 51089-83-9
benzyl 4-ethyl-3-methyl-1H-pyrrole-2-carboxylate

: 97336-23-7
5-(chloromethyl)-2-<2-cyano-2-(methoxycarbonyl)vinyl>-4-ethyl-3-methylpyrrole

: 97336-24-8
5-(benzyloxycarbonyl)-5'-<2-cyano-2-(methoxycarbonyl)vinyl>-3,3'-diethyl-4,4'-dimethyl-2,2'-dipyrromethane

Guidance literature:: In acetic acid;
DOI:10.1021/jo00220a030

Reference yield: 64.0%

: 3750-36-5
benzyl 5-(acetoxymethyl)-4-ethyl-3-methyl-1H-pyrrole-2-carboxylate

: 488091-94-7
2-cyano-3-(4-ethyl-3-methyl-1H-pyrrol-2-yl)-acrylic acid methyl ester

: 97336-24-8
5-[5-(2-cyano-2-methoxycarbonyl-vinyl)-3-ethyl-4-methyl-1H-pyrrol-2-ylmethyl]-4-ethyl-3-methyl-1H-pyrrole-2-carboxylic acid benzyl ester

Guidance literature:: With toluene-4-sulfonic acid; acetic acid;
DOI:10.1016/S0040-4039(02)01958-5

Reference yield:

: 2199-47-5
ethyl 3,5-dimethyl-4-ethylpyrrole-2-carboxylate

: 97336-24-8
5-(benzyloxycarbonyl)-5'-<2-cyano-2-(methoxycarbonyl)vinyl>-3,3'-diethyl-4,4'-dimethyl-2,2'-dipyrromethane

Guidance literature:: Multi-step reaction with 6 steps

1: 17 percent / sodium hydroxide / methanol; H₂O / 2 h / Heating

2: POCl₃ / CH₂Cl₂ / Heating

3: NaHCO₃ / H₂O / 75.7 h

4: 80.6 percent / triethylamine / toluene

5: 84.2 percent / sulfuryl chloride / CH₂Cl₂ / 0.5 h / Ambient temperature

6: 88.1 percent / acetic acid

With sodium hydroxide; sulfuryl dichloride; sodium hydrogencarbonate; triethylamine; trichlorophosphate; In methanol; dichloromethane; water; acetic acid; toluene;
DOI:10.1021/jo00220a030