1-(3-Chlorophenyl)-6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione

Base Information

Chemical Name:1-(3-Chlorophenyl)-6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione
CAS No.:97364-75-5
Molecular Formula:C14H13ClO4
Molecular Weight:280.708
Hs Code.:
DSSTox Substance ID:DTXSID70540125

Synonyms:97364-75-5;DTXSID70540125;1-(3-Chlorophenyl)-6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione

Suppliers and Price of 1-(3-Chlorophenyl)-6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3-Chlorophenyl)-6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:280.0502366
Heavy Atom Count:19
Complexity:411

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(OC(=O)C2(CC2C3=CC(=CC=C3)Cl)C(=O)O1)C

Technology Process of 1-(3-Chlorophenyl)-6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione

There total 1 articles about 1-(3-Chlorophenyl)-6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 15948-53-5
5-[(3-chlorophenyl)methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione

: 70775-39-2,5367-24-8
dimethylsulfoxonium methylide

: 97364-75-5
1-(3-Chloro-phenyl)-6,6-dimethyl-5,7-dioxa-spiro[2.5]octane-4,8-dione

Guidance literature:: In N,N-dimethyl-formamide; at 10 ℃; for 0.25h;
DOI:10.1016/S0040-4020(01)83489-X

Reference yield: 83.0%

: 97364-75-5
1-(3-Chloro-phenyl)-6,6-dimethyl-5,7-dioxa-spiro[2.5]octane-4,8-dione

: 97364-49-3
(1R,2R)-1-Carbamoyl-2-(3-chloro-phenyl)-cyclopropanecarboxylic acid

Guidance literature:: With ammonium hydroxide; In 1,4-dioxane; for 3h;
DOI:10.1016/S0040-4020(01)83489-X

Reference yield:

: 97364-75-5
1-(3-Chloro-phenyl)-6,6-dimethyl-5,7-dioxa-spiro[2.5]octane-4,8-dione

: 97364-36-8,100819-57-6
(1S,2R)-1-Amino-2-(2-chloro-phenyl)-cyclopropanecarboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / conc NH₄OH / dioxane / 3 h

2: 1.) Br₂ / 1.) MeOH, 30-45 min; 2.) MeOH, 1 h; reflux 14 h

3: 41 percent / conc HCl / acetic acid / 48 h / Heating

With hydrogenchloride; ammonium hydroxide; bromine; In 1,4-dioxane; acetic acid;
DOI:10.1016/S0040-4020(01)83489-X