6,6-Dimethyl-1-(4-methylphenyl)-5,7-dioxaspiro[2.5]octane-4,8-dione

Base Information

• Chemical Name: 6,6-Dimethyl-1-(4-methylphenyl)-5,7-dioxaspiro[2.5]octane-4,8-dione
• CAS No.: 97381-39-0
• Molecular Formula: C15H16O4
• Molecular Weight: 260.29
• DSSTox Substance ID: DTXSID90540127
• Nikkaji Number: J2.219.712F
• Mol file: 97381-39-0.mol

Synonyms:6,6-Dimethyl-1-(4-methylphenyl)-5,7-dioxaspiro[2.5]octane-4,8-dione;97381-39-0;DTXSID90540127

Chemical Property of 6,6-Dimethyl-1-(4-methylphenyl)-5,7-dioxaspiro[2.5]octane-4,8-dione

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 260.10485899
• Heavy Atom Count: 19
• Complexity: 398

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2CC23C(=O)OC(OC3=O)(C)C

Technology Process of 6,6-Dimethyl-1-(4-methylphenyl)-5,7-dioxaspiro[2.5]octane-4,8-dione

There total 3 articles about 6,6-Dimethyl-1-(4-methylphenyl)-5,7-dioxaspiro[2.5]octane-4,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2,2-dimethyl-5-(4-methylbenzylidene)-1,3-dioxane-4,6-dione (15795-51-4) + dimethylsulfoxonium methylide (70775-39-2,5367-24-8) → 6,6-Dimethyl-1-p-tolyl-5,7-dioxa-spiro[2.5]octane-4,8-dione (97381-39-0)

Guidance literature:

In N,N-dimethyl-formamide; at 10 ℃; for 0.25h;

DOI:10.1016/S0040-4020(01)83489-X

Reference yield: 19.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2,2-dimethyl-5-(4-methylbenzylidene)-1,3-dioxane-4,6-dione (15795-51-4) → 6,6-Dimethyl-1-(4-methyl-benzyl)-5,7-dioxa-spiro[2.5]octane-4,8-dione (97381-42-5) + 6,6-Dimethyl-1-p-tolyl-5,7-dioxa-spiro[2.5]octane-4,8-dione (97381-39-0)

Guidance literature:

In methanol; diethyl ether; at -70 ℃; for 1h;

DOI:10.1016/S0040-4020(01)83489-X

Reference yield:

cycl-isopropylidene malonate (2033-24-1) + 1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) → 6,6-Dimethyl-1-p-tolyl-5,7-dioxa-spiro[2.5]octane-4,8-dione (97381-39-0)

Guidance literature:

With aluminum oxide; [bis(acetoxy)iodo]benzene; dirhodium tetraacetate; In dichloromethane; at 30 ℃;

DOI:10.1007/s00706-005-0299-6

upstream raw materials:

diazomethane

2,2-dimethyl-5-(4-methylbenzylidene)-1,3-dioxane-4,6-dione

dimethylsulfoxonium methylide

cycl-isopropylidene malonate

Downstream raw materials:

(1R,2R)-1-Carbamoyl-2-p-tolyl-cyclopropanecarboxylic acid

(3S,5R)-2-Oxo-5-p-tolyl-pyrrolidine-3-carboxylic acid

(3R,5R)-2-Oxo-5-p-tolyl-pyrrolidine-3-carboxylic acid

(1R,2S)-2-p-Tolyl-cyclopropane-1,1-dicarboxylic acid methyl ester