1H-Indole, 1,2,4,6-tetramethyl-

Base Information

• Chemical Name: 1H-Indole, 1,2,4,6-tetramethyl-
• CAS No.: 97799-86-5
• Molecular Formula: C12H15N
• Molecular Weight: 173.258
• DSSTox Substance ID: DTXSID40471634
• Wikidata: Q82300220
• Mol file: 97799-86-5.mol

Synonyms:1,2,4,6-tetramethylindole;1H-Indole, 1,2,4,6-tetramethyl-;97799-86-5;SCHEMBL21983592;DTXSID40471634

Chemical Property of 1H-Indole, 1,2,4,6-tetramethyl-

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 173.120449483
• Heavy Atom Count: 13
• Complexity: 190

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=C2C=C(N(C2=C1)C)C)C

Technology Process of 1H-Indole, 1,2,4,6-tetramethyl-

There total 10 articles about 1H-Indole, 1,2,4,6-tetramethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1,2,4,6-tetramethyl-3-nitropyridinium iodide (65081-41-6) + (1S)-N-(1-methylethylidene)-1-phenylethylamine (75815-80-4) → 1,2,4,6,-tetramethylindole (97799-86-5) + (S)-1-(1-methylbenzyl)-2,4,6-trimethylindole

Guidance literature:

In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1016/0957-4166(95)00379-7

Reference yield: 62.0%

methyl-1 ethylideneamine (6407-34-7,19885-74-6) + 1,2,4,6-tetramethyl-3-nitropyridinium iodide (65081-41-6) → 1,2,4,6,-tetramethylindole (97799-86-5)

Guidance literature:

In N,N-dimethyl-formamide; for 24h;

DOI:10.1007/BF00470027

Reference yield: 62.0%

methyl-1 ethylideneamine (6407-34-7,19885-74-6) + 1,2,4,6-tetramethyl-3-nitropyridinium iodide (65081-41-6) → 1,2,4,6,-tetramethylindole (97799-86-5) + 1,2,2,5,7-Pentamethyl-4-methylene-6-nitro-1,2,3,4-tetrahydro-quinoline (118967-30-9) + 1,2,2,4,5,7-Hexamethyl-6-nitro-1,2-dihydro-quinoline (118967-28-5)

Guidance literature:

In N,N-dimethyl-formamide; Product distribution; Mechanism;

DOI:10.1007/BF00475614

upstream raw materials:

piperidine

1,2,4,6-tetramethyl-3-nitropyridinium iodide

acetone

methyl-1 ethylideneamine

Downstream raw materials:

3-(4-methoxyphenyl)-1,2,4,6-tetramethylindole