4-(5-Bromothiophen-2-yl)thiazol-2-amine

Base Information

• Chemical Name: 4-(5-Bromothiophen-2-yl)thiazol-2-amine
• CAS No.: 34801-14-4
• Molecular Formula: C7H5BrN2S2
• Molecular Weight: 261.166
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID70956282
• Wikidata: Q72442504
• Mol file: 34801-14-4.mol

Synonyms:4-(5-bromothiophen-2-yl)thiazol-2-amine;34801-14-4;4-(5-bromo-2-thienyl)-1,3-thiazol-2-amine;4-(5-bromothiophen-2-yl)-1,3-thiazol-2-amine;175135-92-9;4-(5-Bromothiophen-2-yl)thiazol-2-ylamine;2-amino-4-(5-bromothien-2-yl)thiazole;2-AMINO-4-(5-BROMOTHIOPHEN-2-YL)THIAZOLE;4-(5-Bromo-thiophen-2-yl)-thiazol-2-ylamine;Maybridge1_001930;SCHEMBL3418282;HMS546P16;DTXSID70956282;MMZHPDCFNLBMBY-UHFFFAOYSA-N;MFCD01812622;SC2191;STK312717;AKOS000122285;4-(5-Bromo-2-thienyl)-2-thiazolamine;AS-54617;4-(5-bromo-2-thiophenyl)-2-thiazolamine;CS-0200092;FT-0616673;EN300-02233;A822405;4-(5-bromanylthiophen-2-yl)-1,3-thiazol-2-amine;J-019762;J-513589;4-(5-Bromothiophen-2-yl)-1,3-thiazol-2(3H)-imine;BRD-K05621897-001-01-7;Z48847662;F0214-0069

Chemical Property of 4-(5-Bromothiophen-2-yl)thiazol-2-amine

Chemical Property:

• Vapor Pressure: 2.34E-06mmHg at 25°C
• Melting Point: 151℃
• Refractive Index: 1.723
• Boiling Point: 392.1 °C at 760 mmHg
• Flash Point: 191 °C
• PSA: 95.39000
• Density: 1.796 g/cm³
• LogP: 3.79750
• Storage Temp.: 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 259.90775
• Heavy Atom Count: 12
• Complexity: 170

Purity/Quality:

97% ^*data from raw suppliers

4-(5-Bromo-2-thienyl)-1,3-thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-36/37/38-22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(SC(=C1)Br)C2=CSC(=N2)N

Technology Process of 4-(5-Bromothiophen-2-yl)thiazol-2-amine

There total 4 articles about 4-(5-Bromothiophen-2-yl)thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(2-bromoacetyl)-5-bromothiophene (10531-44-9) + thiourea (17356-08-0) → 4-(5-bromo-2-thienyl)-1,3-thiazol-2-amine (34801-14-4)

Guidance literature:

In ethanol; at 70 ℃;

Reference yield: 71.0%

ammonium thiocyanate + 2-(2-bromoacetyl)-5-bromothiophene (10531-44-9) → 4-(5-bromo-2-thienyl)-1,3-thiazol-2-amine (34801-14-4)

Guidance literature:

With 1-methyl-1H-imidazole; In water; isopropyl alcohol; at 20 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2012.07.080

Reference yield:

2-Acetyl-5-bromothiophene (5370-25-2) → 4-(5-bromo-2-thienyl)-1,3-thiazol-2-amine (34801-14-4)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(ll) bromide / ethyl acetate; chloroform / Reflux

2: ethanol / 70 °C

With copper(ll) bromide; In ethanol; chloroform; ethyl acetate;

upstream raw materials:

2-(2-bromoacetyl)-5-bromothiophene

thiourea

2-Acetyl-5-bromothiophene

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