Chemical Property of Lanicemine
Chemical Property:
- Vapor Pressure:0.000712mmHg at 25°C
- Boiling Point:307.7°Cat760mmHg
- PKA:8.29±0.10(Predicted)
- Flash Point:160.5°C
- PSA：38.91000
- Density:1.097g/cm3
- LogP:3.02440
- Solubility.:≤20mg/ml in ethanol;30mg/ml in DMSO;5mg/ml in dimethyl formamide
- XLogP3:1.7
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:3
- Exact Mass:198.115698455
- Heavy Atom Count:15
- Complexity:175
- Purity/Quality:
-
99%, *data from raw suppliers
Lanicemine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
Useful:
- Canonical SMILES:C1=CC=C(C=C1)C(CC2=CC=CC=N2)N
- Isomeric SMILES:C1=CC=C(C=C1)[C@H](CC2=CC=CC=N2)N
- Recent ClinicalTrials:NMDA Receptor Modulation for Hyperarousal in PTSD
- Recent EU Clinical Trials:A Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled, Phase IIb Efficacy and Safety Study of Adjunctive AZD6765 in Patients with Major Depressive Disorder (MDD) and a History of Inadequate Response to Antidepressants.
-
Description
Lanicemine is a non-selective, voltage-dependent NMDA channel blocker (IC50 = 4-7 μM) that binds to sites within the channel pore with a Ki value of 0.56-2.1 μM. Compared to ketamine , lanicemine exhibits a lower propensity to be trapped within the NMDA channel (86% versus 54% trapping) following removal and reapplication of glutamate. It has been examined for its potential to produce antidepressant effects without adverse psychotomimetic activity.
-
Uses
Lanicemine is a non-selective voltage-dependant NMDA channel blocker. It is a potential anti-depressant which does not cause psychotomimetic activity. Potential anti-hypertensive agent.
