4-Pyridazinecarboxylic acid, 5-(2-phenylethyl)-, ethyl ester

Base Information

• Chemical Name: 4-Pyridazinecarboxylic acid, 5-(2-phenylethyl)-, ethyl ester
• CAS No.: 98832-85-0
• Molecular Formula: C15H16N2O2
• Molecular Weight: 256.304
• Mol file: 98832-85-0.mol

Synonyms:

Chemical Property of 4-Pyridazinecarboxylic acid, 5-(2-phenylethyl)-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Pyridazinecarboxylic acid, 5-(2-phenylethyl)-, ethyl ester

There total 2 articles about 4-Pyridazinecarboxylic acid, 5-(2-phenylethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

2-oxo-propionic acid ethyl ester (617-35-6) + 4-(2-phenylethyl)-pyridazine (50901-49-0) → ethyl 5-(2-phenylethyl)-4-pyridazinedicarboxylate (98832-85-0) + diethyl 5-(2-phenylethyl)-3,4-pyridazinedicarboxylate (98832-87-2) + diethyl 4-(2-phenylethyl)-3,5-pyridazinedicarboxylate (98832-86-1) + triethyl 5-(2-phenylethyl)-3,4,6-pyridazinetricarboxylate (98832-88-3)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; Yield given. Multistep reaction; 1.) -10 - 0 deg C (adding), then 15 min, 2.) H₂O, -5 - 0 deg C (adding), then 15 min;

DOI:10.1016/S0040-4020(01)96521-4

Reference yield: 1.0%

2-oxo-propionic acid ethyl ester (617-35-6) + 4-(2-phenylethyl)-pyridazine (50901-49-0) → ethyl 5-(2-phenylethyl)-4-pyridazinedicarboxylate (98832-85-0) + diethyl 4-(2-phenylethyl)-3,5-pyridazinedicarboxylate (98832-86-1)

Guidance literature:

With sulfuric acid; dihydrogen peroxide; Yield given. Multistep reaction; 1.) -10 - 0 deg C (adding), then 15 min, 2.) CH₂Cl₂, H₂O, -5 - 0 deg C (adding), then 15 min;

DOI:10.1016/S0040-4020(01)96521-4

Reference yield: 85.0%

ethyl 5-(2-phenylethyl)-4-pyridazinedicarboxylate (98832-85-0) → 5-(2-Phenylethyl)-4-pyridazinecarboxylic acid

Guidance literature:

With sodium hydroxide; In ethanol; for 2h; Heating;

DOI:10.1007/BF00809689

upstream raw materials:

2-oxo-propionic acid ethyl ester

4-(2-phenylethyl)-pyridazine