(L)-METHIONYL-(L)-PROLYL-P-NITROANILIDE

Base Information

• Chemical Name: (L)-METHIONYL-(L)-PROLYL-P-NITROANILIDE
• CAS No.: 99264-69-4
• Molecular Formula: C16H22N4O4S
• Molecular Weight: 366.441
• Hs Code.: 2933990090
• Mol file: 99264-69-4.mol

Synonyms:Met-Pro-pNA;Metopimazine Acid;

Chemical Property of (L)-METHIONYL-(L)-PROLYL-P-NITROANILIDE

Chemical Property:

• PSA: 146.55000
• LogP: 2.83910

Purity/Quality:

97% ^*data from raw suppliers

(L)-METHIONYL-(L)-PROLYL-PARA-NITROANILIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (L)-METHIONYL-(L)-PROLYL-P-NITROANILIDE

There total 5 articles about (L)-METHIONYL-(L)-PROLYL-P-NITROANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C21H30N4O6S → Met-Pro-pNA (99264-69-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmcl.2013.10.071

Reference yield:

(S)-N-(4-nitrophenyl)pyrrolidine-2-carboxamide (64155-02-8,7369-91-7) → Met-Pro-pNA (99264-69-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 5 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With dmap; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2013.10.071

Reference yield:

tert-butyl (S)-2-((4-nitrophenyl)carbamoyl)pyrrolidine-1-carboxylate (97885-49-9) → Met-Pro-pNA (99264-69-4)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

2: dicyclohexyl-carbodiimide; dmap / dichloromethane / 5 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With dmap; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2013.10.071

upstream raw materials:

tert-butyl (S)-2-((4-nitrophenyl)carbamoyl)pyrrolidine-1-carboxylate

(S)-N-(4-nitrophenyl)pyrrolidine-2-carboxamide

1-(tert-butoxycarbonyl)-L-proline

4-nitro-aniline