Cyclopentanone, 2-hydroxy-, (2R)-

Base Information

• Chemical Name: Cyclopentanone, 2-hydroxy-, (2R)-
• CAS No.: 99493-88-6
• Molecular Formula: C5H8O2
• Mol file: 99493-88-6.mol

Synonyms:

Chemical Property of Cyclopentanone, 2-hydroxy-, (2R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentanone, 2-hydroxy-, (2R)-

There total 15 articles about Cyclopentanone, 2-hydroxy-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2-acetoxycyclopentanone (52789-75-0) → (R)-2-hydroxycyclopentanone (99493-88-6,473-84-7) + (S)-(+)-2-acetoxycyclopentanone

Guidance literature:

With ammonium sulfate; phosphate buffer; pig liver esterase; at 20 ℃; for 8h; pH=7.00;

DOI:10.1016/j.tetasy.2004.04.019

Reference yield: 45.0%

2-acetoxycyclopentanone (52789-75-0) → (R)-2-hydroxycyclopentanone (99493-88-6,473-84-7) + (2S)-2-hydroxycyclopentan-1-one (147333-12-8,473-84-7) + (S)-(+)-2-acetoxycyclopentanone

Guidance literature:

With Amano PS Lipase; In water; Petroleum ether; benzene; at 25 ℃; for 22h; pH=6.5; Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(02)00366-X

Reference yield: 33.9%

trans-cyclopentane-1,2-diol (5057-99-8,86703-52-8) → (S,S)-cyclopentane-1,2-diol (63261-45-0,86703-52-8) + (R)-2-hydroxycyclopentanone (99493-88-6,473-84-7)

Guidance literature:

With 2,3-butanediol dehydrogenase from Bacillus subtilis; In aq. buffer; at 30 ℃; for 4h; pH=8; Reagent/catalyst; enantioselective reaction; Enzymatic reaction;

DOI:10.1002/adsc.201300301

upstream raw materials:

trans-cyclopentane-1,2-diol

2-hydroxycyclopentanone

2-acetoxycyclopentanone

cyclopentanone