2-(Bromomethyl)-5-chloro-1-benzothiophene

Base Information

• Chemical Name: 2-(Bromomethyl)-5-chloro-1-benzothiophene
• CAS No.: 99592-53-7
• Molecular Formula: C9H6BrClS
• Molecular Weight: 261.57
• Hs Code.: 2934999090
• Mol file: 99592-53-7.mol

Synonyms:2-bromomethyl-5-chlorobenzo[b]thiophene;bromomethylchlorobenzothiophene;Benzo[b]thiophene,2-(bromomethyl)-5-chloro;2-(3-FLUORO-PHENYL)-ETHANESULFONYL CHLORIDE;

Chemical Property of 2-(Bromomethyl)-5-chloro-1-benzothiophene

Chemical Property:

• PSA: 28.24000
• LogP: 4.44960

Purity/Quality:

98%min ^*data from raw suppliers

2-(Bromomethyl)-5-chloro-1-benzothiophene >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Bromomethyl)-5-chloro-1-benzothiophene

There total 6 articles about 2-(Bromomethyl)-5-chloro-1-benzothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-chloro-2-methylbenzo[b]thiophene (30489-80-6) → 2-bromomethyl-5-chlorobenzo[b]thiophene (99592-53-7)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; at 70 ℃; for 0.5h; Heating / reflux;

Reference yield:

2-Hydroxymethyl-5-chlor-benzothiophen (13771-71-6) → 2-bromomethyl-5-chlorobenzo[b]thiophene (99592-53-7)

Guidance literature:

With phosphorus tribromide; In diethyl ether; at 0 ℃; for 2h;

Reference yield:

p-Chlorothiophenol (106-54-7) → 2-bromomethyl-5-chlorobenzo[b]thiophene (99592-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) N,N-dimethylaniline / 2.) heating

2: 38 percent / NBS, PhCO₂O₂CPh / Irradiation

With N-Bromosuccinimide; N,N-dimethyl-aniline; dibenzoyl peroxide;

DOI:10.1002/mrc.1260231006

upstream raw materials:

5-chloro-2-methylbenzo[b]thiophene

p-Chlorothiophenol

2-chloro-3-(4-chlorophenylthio)propene

5-chlorobenzothiophene

Downstream raw materials:

1-<2-<(5-chloro-2-benzothienyl)methoxy>-2-(2,4-dichlorophenyl)ethyl>-1H-imidazol

1-(2,4-Dichloro-phenyl)-2-imidazol-1-yl-ethanone O-(5-chloro-benzo[b]thiophen-2-ylmethyl)-oxime

Refernces

• 1、 -. "N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS". . . Retrieved 2015/05/19.
• 2、 -. "Hypoglycemic imidazoline compounds". Page 39-40. . Retrieved 2010/11/29.