2-aMino-3-phenylphenol

Base Information

• Chemical Name: 2-aMino-3-phenylphenol
• CAS No.: 109877-38-5
• Molecular Formula: C12H11NO
• Molecular Weight: 185.225
• Mol file: 109877-38-5.mol

Synonyms:2-amino-3-hydroxybiphenyl;3-hydroxybiphenyl-2-amine;

Chemical Property of 2-aMino-3-phenylphenol

Chemical Property:

• PSA: 46.25000
• LogP: 3.22260

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-aMino-3-phenylphenol

There total 7 articles about 2-aMino-3-phenylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-nitro-3-hydroxybiphenyl (21419-74-9) → 2-amino-3-hydroxybiphenyl (109877-38-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 6h;

DOI:10.1016/j.bmc.2012.07.023

Reference yield: 80.0%

2,4-diphenylbenzo[d]oxazole → 2-amino-3-hydroxybiphenyl (109877-38-5)

Guidance literature:

With hydrazine hydrate; potassium hydroxide; In dimethyl sulfoxide; at 120 ℃; for 16h; Sealed tube;

DOI:10.1039/d0ob00061b

Reference yield:

N-(2-hydroxyphenyl)benzamide (3743-70-2) → 2-amino-3-hydroxybiphenyl (109877-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium diacetate / trifluoroacetic acid / 1 h / 20 °C

1.2: 14 h / 80 °C

2.1: hydrazine hydrate; potassium hydroxide / dimethyl sulfoxide / 16 h / 120 °C / Sealed tube

With palladium diacetate; hydrazine hydrate; potassium hydroxide; In dimethyl sulfoxide; trifluoroacetic acid;

DOI:10.1039/d0ob00061b

upstream raw materials:

[1,1'-biphenyl]-3-ol

2-nitro-3-hydroxybiphenyl

iodobenzene

N-(2-hydroxyphenyl)benzamide

Downstream raw materials:

tert-butyl (2-oxo-4-phenyl-1,3-benzoxazol-3(2H)-yl)acetate

(2-oxo-4-phenyl-1,3-benzoxazol-3(2H)-yl)acetic acid

C₂₂H₁₈N₂O₃

4-phenyl-1,3-benzoxazol-2(3H)-one