AS703026

Base Information

• Chemical Name: AS703026
• CAS No.: 1236699-92-5
• Molecular Formula: C15H15FIN3O3
• Molecular Weight: 431.2008
• Hs Code.: 2933399990
• Mol file: 1236699-92-5.mol

Synonyms:Pimasertib

Chemical Property of AS703026

Chemical Property:

• Boiling Point: 623.24 °C at 760 mmHg
• PKA: 12.82±0.46(Predicted)
• Flash Point: 330.724 °C
• PSA: 94.48000
• Density: 1.769 g/cm³
• LogP: 2.11580
• Solubility.: ≥21.55 mg/mL in DMSO; insoluble in H2O; ≥10.36 mg/mL in EtOH with ultrasonic

Purity/Quality:

98% ^*data from raw suppliers

AS-703026 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor, in human multiple myeloma (MM). AS703026 induces pleiotropic anti-myeloma activity in vitro and in vivo. MEK inhibitors are useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation.

Technology Process of AS703026

There total 2 articles about AS703026 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-((S)-2,3-dihydroxy-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide monohydrochloride → N-((S)-2,3-dihydroxy-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide (1236699-92-5)

Guidance literature:

With sodium hydroxide; In water; at 23 ℃; for 0.166667h;

Reference yield:

→ N-((S)-2,3-dihydroxy-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide (1236699-92-5)

Guidance literature:

Refernces

• 1、 -. "3-ARYLAMINO PYRIDINE DERIVATIVES". Page/Page column 76. . Retrieved 2008/06/13.