Piperidine-3,5-dione hydrochloride

Base Information

• Chemical Name: Piperidine-3,5-dione hydrochloride
• CAS No.: 74647-23-7
• Molecular Formula: C₅H₇NO₂*ClH
• Molecular Weight: 149.577
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10505213
• Mol file: 74647-23-7.mol

Synonyms:PIPERIDINE-3,5-DIONE HYDROCHLORIDE;74647-23-7;PIPERIDINE-3,5-DIONE HCL;piperidine-3,5-dione;hydrochloride;MFCD17676319;3,5-Piperidinedione, hydrochloride;DTXSID10505213;ZCA64723;AKOS006381766;SB38548;PIPERIDINE-3,5-DIONEHYDROCHLORIDE;SY263702;CS-0342703;Piperidine-3,5-dione--hydrogen chloride (1/1)

Chemical Property of Piperidine-3,5-dione hydrochloride

Chemical Property:

• Melting Point: 170-173 °C
• PSA: 46.17000
• LogP: 0.24870
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 149.0243562
• Heavy Atom Count: 9
• Complexity: 116

Purity/Quality:

98%,99%, ^*data from raw suppliers

Piperidine-3,5-dionehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(=O)CNCC1=O.Cl

Technology Process of Piperidine-3,5-dione hydrochloride

There total 1 articles about Piperidine-3,5-dione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzylpiperidine-3,5-dione hydrochloride (73385-13-4) → piperidine-3,5-dione hydrochloride (74647-23-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water; Ambient temperature;

DOI:10.1002/jhet.5570170101

Reference yield:

piperidine-3,5-dione hydrochloride (74647-23-7) → 1-Carboethoxy-3-anilino-5-oxo-3,4-dehydropiperidine (74647-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / H₂O / 3 h / Ambient temperature

2: 42 percent / ethanol

With potassium carbonate; In ethanol; water;

DOI:10.1002/jhet.5570170101

Reference yield:

piperidine-3,5-dione hydrochloride (74647-23-7) → 1-Carboethoxy-3-anilino-4-diethylaminomethyl-5-oxo-3,4-dehydropiperidine (74663-39-1)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / H₂O / 3 h / Ambient temperature

2: 42 percent / ethanol

3: 73 percent / acetic acid / aq. ethanol

With potassium carbonate; acetic acid; In ethanol; water;

DOI:10.1002/jhet.5570170101

upstream raw materials:

N-benzylpiperidine-3,5-dione hydrochloride

Downstream raw materials:

N-Acetylpiperidine-3,5-dione

1-Acetyl-3-anilino-5-oxo-3,4-dehydropiperidine

1-Carboethoxy-3-anilino-5-oxo-3,4-dehydropiperidine

1-Acetyl-3-anilino-4-diethylaminomethyl-5-oxo-3,4-dehydropiperidine

Refernces