Rosuvastatin Intermediates

Base Information

• Chemical Name: Rosuvastatin Intermediates
• CAS No.: 937639-31-1
• Molecular Formula: C₂₀H₂₉FN₃O₅PS
• Molecular Weight: 473.506
• DSSTox Substance ID: DTXSID90586282
• Wikidata: Q72476160
• Mol file: 937639-31-1.mol

Synonyms:Rosuvastatin Intermediates;937639-31-1;N-[5-(diethoxyphosphorylmethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide;diethyl ((4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)methyl)phosphonate;diethyl {[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]methyl}phosphonate;RosuvastatinIntermediates;P-[[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]methyl]phosphonic acid diethyl ester;DTXSID90586282;AKOS000280944;DB-210084;A922397;Diethyl {[4-(4-fluorophenyl)-2-[(methanesulfonyl)(methyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]methyl}phosphonate

Chemical Property of Rosuvastatin Intermediates

Chemical Property:

• Appearance/Colour: white or almost white power
• Boiling Point: 609.4±65.0 °C(Predicted)
• PKA: -0.35±0.10(Predicted)
• PSA: 116.88000
• Density: 1.267
• LogP: 5.64880
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 10
• Exact Mass: 473.15495737
• Heavy Atom Count: 31
• Complexity: 702

Purity/Quality:

98%,99%, ^*data from raw suppliers

RosuvastatinIntermediates 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOP(=O)(CC1=C(N=C(N=C1C(C)C)N(C)S(=O)(=O)C)C2=CC=C(C=C2)F)OCC

Technology Process of Rosuvastatin Intermediates

There total 1 articles about Rosuvastatin Intermediates which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.3%

N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide (799842-07-2) + triethyl phosphite (122-52-1) → C20H29FN3O5PS (937639-31-1)

Guidance literature:

at 80 - 85 ℃; Inert atmosphere;

upstream raw materials:

N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide

triethyl phosphite

Refernces