Methyl 4-bromoquinoline-6-carboxylate

Base Information

Chemical Name:Methyl 4-bromoquinoline-6-carboxylate
CAS No.:219763-85-6
Molecular Formula:C11H8BrNO2
Molecular Weight:266.0907
Hs Code.:2933499090
European Community (EC) Number:803-092-8
DSSTox Substance ID:DTXSID40583004
Wikidata:Q82474516
Mol file:219763-85-6.mol

Synonyms:Methyl 4-bromoquinoline-6-carboxylate;219763-85-6;Methyl 4-bromo-6-quinolinecarboxylate;SCHEMBL6298726;DTXSID40583004;ROTWWLOBDCESBP-UHFFFAOYSA-N;AMY26965;Methyl4-bromoquinoline-6-carboxylate;MFCD12964065;SB71910;WS-02438;CS-0361860;Methyl 4-bromoquinoline-6-carboxylate, 95%;F20039;EN300-9538548;A878842

Suppliers and Price of Methyl 4-bromoquinoline-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Methyl 4-bromoquinoline-6-carboxylate 95%
1g
$ 74.80

Crysdot
Methyl 4-bromoquinoline-6-carboxylate 95+%
5g
$ 628.00

Chemenu
Methyl 4-bromoquinoline-6-carboxylate 95%
5g
$ 593.00

Chemcia Scientific
4-Bromo-quinoline-6-carboxylicacidmethylester 95%
1 G
$ 395.00

Total 9 raw suppliers

Chemical Property of Methyl 4-bromoquinoline-6-carboxylate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:145-150°C
Boiling Point:368.669°C at 760 mmHg
Flash Point:176.765°C
PSA：39.19000
Density:1.557g/cm³
LogP:2.78390
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:264.97384
Heavy Atom Count:15
Complexity:247

Purity/Quality:

97% ^*data from raw suppliers

Methyl 4-bromoquinoline-6-carboxylate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CC2=C(C=CN=C2C=C1)Br

Technology Process of Methyl 4-bromoquinoline-6-carboxylate

There total 7 articles about Methyl 4-bromoquinoline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 933486-45-4,948571-56-0
methyl 4-hydroxyquinoline-6-carboxylate

: 219763-85-6
4-bromoquinoline-6-carboxylic acid methyl ester

Guidance literature:: With phosphorus tribromide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1021/jo062168u

Reference yield:

: 219763-84-5
methyl 4-methoxyquinoline-6-carboxylate

: 219763-85-6
4-bromoquinoline-6-carboxylic acid methyl ester

Guidance literature:: With phosphorus tribromide; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 3h; Heating / reflux;

Reference yield:

: 619-45-4
4-methoxycarbonyl aniline

: 219763-85-6
4-bromoquinoline-6-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: HC(OEt)3 / 145 °C

1.2: 50 - 145 °C

1.3: diphenyl ether / 250 °C

2.1: 99 percent / PBr₃ / dimethylformamide / 0.5 h / 20 °C

With phosphorus tribromide; orthoformic acid triethyl ester; In N,N-dimethyl-formamide;
DOI:10.1021/jo062168u