(2-Chlorothiazol-5-yl)methylamine hydrochloride

Base Information

• Chemical Name: (2-Chlorothiazol-5-yl)methylamine hydrochloride
• CAS No.: 153471-67-1
• Molecular Formula: C₄H₅ClN₂S*ClH
• Molecular Weight: 185.077
• Hs Code.: 2934100090
• European Community (EC) Number: 832-730-8
• DSSTox Substance ID: DTXSID90592989
• Mol file: 153471-67-1.mol

Synonyms:153471-67-1;(2-Chlorothiazol-5-yl)methylamine hydrochloride;(2-chlorothiazol-5-yl)methanamine hydrochloride;(2-CHLOROTHIAZOL-5-YL)METHYLAMINE HCL;C4H6Cl2N2S;C-(2-Chloro-thiazol-5-yl)-methylamine hydrochloride;(2-chloro-1,3-thiazol-5-yl)methanamine hydrochloride;(2-chloro-1,3-thiazol-5-yl)methanamine;hydrochloride;5-(aminomethyl)-2-chlorothiazole hydrochloride;5-Thiazolemethanamine, 2-chloro-, monohydrochloride;1-(2-CHLORO-1,3-THIAZOL-5-YL)METHANAMINE HYDROCHLORIDE;LEADTRI-N-BUTYLACETATE;SCHEMBL2091063;DTXSID90592989;QWCUHOCIRYNOOH-UHFFFAOYSA-N;AMY22916;MFCD09039253;AKOS015846535;GS-4521;SB33849;DB-001875;CS-0067898;(2-chlorothiazol-5-yl)methanaminehydrochloride;EN300-199048;A883816;J-500726;Z1741976615;1-(2-Chloro-1,3-thiazol-5-yl)methanamine--hydrogen chloride (1/1)

Chemical Property of (2-Chlorothiazol-5-yl)methylamine hydrochloride

Chemical Property:

• PSA: 67.15000
• LogP: 2.75750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 183.9628748
• Heavy Atom Count: 9
• Complexity: 80.4

Purity/Quality:

97% ^*data from raw suppliers

(2-Chlorothiazol-5-yl)methylamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(SC(=N1)Cl)CN.Cl

Technology Process of (2-Chlorothiazol-5-yl)methylamine hydrochloride

There total 1 articles about (2-Chlorothiazol-5-yl)methylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3,5-tris{(2-chloro-1,3-thiazol-5-yl)methyl}-1,3,5-hexahydrotriazine (872165-33-8) → 2-chloro-5-(aminomethyl)thiazole hydrochloride (153471-67-1) + bis{(2-chlorothiazol-5-yl)methyl}amine (434902-57-5)

Guidance literature:

1,3,5-tris{(2-chloro-1,3-thiazol-5-yl)methyl}-1,3,5-hexahydrotriazine; With hydroxyammonium sulfate; water; In toluene; for 2.5h;

With hydrogenchloride; water; In toluene; at 20 - 30 ℃; for 2.5h;

With hydrogenchloride; sodium hydroxide; more than 3 stages; Product distribution / selectivity;

Reference yield: 92.6%

2-chloro-5-(aminomethyl)thiazole hydrochloride (153471-67-1) → bis{(2-chlorothiazol-5-yl)methyl}amine (434902-57-5)

Guidance literature:

With hydrogenchloride; hydroxyammonium sulfate; In water; toluene; at 20 - 30 ℃; for 1.5h; Temperature;

upstream raw materials:

1,3,5-tris{(2-chloro-1,3-thiazol-5-yl)methyl}-1,3,5-hexahydrotriazine

Downstream raw materials:

bis{(2-chlorothiazol-5-yl)methyl}amine