5-Biphenyl-4-yl-1H-pyrazole-3-carboxylic acid

Base Information

Chemical Name:5-Biphenyl-4-yl-1H-pyrazole-3-carboxylic acid
CAS No.:1037816-85-5
Molecular Formula:C16H12N2O2
Molecular Weight:264.28
Hs Code.:2933199090
DSSTox Substance ID:DTXSID90397734
Wikidata:Q82199305
ChEMBL ID:CHEMBL3593612

Synonyms:5-Biphenyl-4-yl-1H-pyrazole-3-carboxylic acid;1037816-85-5;3-(4-phenylphenyl)-1H-pyrazole-5-carboxylic acid;5-([1,1'-BIPHENYL]-4-YL)-1H-PYRAZOLE-3-CARBOXYLIC ACID;5-{[1,1'-biphenyl]-4-yl}-1H-pyrazole-3-carboxylic acid;5-Biphenyl-4-yl-1H-pyrazole-3-carboxylicacid;3-biphenyl-4-yl-1{H}-pyrazole-5-carboxylic acid;DTXSID90397734;AMY32313;MFCD05170072;AKOS005207381;AKOS009122249;DS-2028;FT-0750319;EN300-236320;5-(4-Phenylphenyl)-1H-pyrazole-3-carboxylic acid;F1967-0137

Suppliers and Price of 5-Biphenyl-4-yl-1H-pyrazole-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 18 raw suppliers

Chemical Property of 5-Biphenyl-4-yl-1H-pyrazole-3-carboxylic acid

Chemical Property:

PSA：65.98000
LogP:3.44190
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:264.089877630
Heavy Atom Count:20
Complexity:333

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CC=C(C=C2)C3=NNC(=C3)C(=O)O

Technology Process of 5-Biphenyl-4-yl-1H-pyrazole-3-carboxylic acid

There total 5 articles about 5-Biphenyl-4-yl-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 85763-16-2
4-((1,1'-biphenyl)-4-yl)-2,4-dioxobutanoic acid

: 1037816-85-5
5-((1,1'-biphenyl)-4-yl)-1H-pyrazole-3-carboxylic acid

Guidance literature:: With hydrazine hydrate; acetic acid; at 20 ℃;
DOI:10.1016/j.bmc.2015.05.052

Reference yield:

: 92-91-1
biphenyl-4-acetaldehyde

: 1037816-85-5
5-((1,1'-biphenyl)-4-yl)-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium

2: aqueous ethanol; N₂H₄*HCl

3: ethanolic KOH

With potassium hydroxide; hydrazine hydrochloride; ethanol; sodium;

Reference yield:

: 92-52-4,1594-86-1
biphenyl

: 1037816-85-5
5-((1,1'-biphenyl)-4-yl)-1H-pyrazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: aluminum (III) chloride / dichloromethane / 6 h / 0 - 20 °C

2: sodium methylate / methanol / 15 h / 20 °C

3: acetic acid; hydrazine hydrate / 20 °C

With aluminum (III) chloride; sodium methylate; hydrazine hydrate; acetic acid; In methanol; dichloromethane; 1: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmc.2015.05.052