N-[1-(1-benzofuran-2-yl)-1,3-dihydroxypropan-2-yl]-2,2-dichloroacetamide

Base Information

Chemical Name:N-[1-(1-benzofuran-2-yl)-1,3-dihydroxypropan-2-yl]-2,2-dichloroacetamide
CAS No.:77612-14-7
Molecular Formula:C₁₃H₁₃Cl₂NO₄
Molecular Weight:318.157
Hs Code.:

Synonyms:ACETAMIDE,N-(2-(2-BENZOFURANYL)-2-HYDROXY-1-(HYDROXYMETHYL)ETHYL)-2,2-DICHLORO-;N-(2-Benzofuran-2-yl-2-hydroxy-1-hydroxymethyl-ethyl)-2,2-dichloro-acetamide;dl-threo-2-dichloroacetamido-1-(2-benzofuranyl)-propane-1,3-diol;

Suppliers and Price of N-[1-(1-benzofuran-2-yl)-1,3-dihydroxypropan-2-yl]-2,2-dichloroacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[1-(1-benzofuran-2-yl)-1,3-dihydroxypropan-2-yl]-2,2-dichloroacetamide

Chemical Property:

Vapor Pressure:1.48E-15mmHg at 25°C
Boiling Point:606.4°Cat760mmHg
Flash Point:320.5°C
PSA：82.70000
Density:1.487g/cm³
LogP:2.13790

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-[1-(1-benzofuran-2-yl)-1,3-dihydroxypropan-2-yl]-2,2-dichloroacetamide

There total 5 articles about N-[1-(1-benzofuran-2-yl)-1,3-dihydroxypropan-2-yl]-2,2-dichloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 74599-87-4
2-dichloroacetamido-3-hydroxy-1-(2-benzofuranyl)-1-propanone

: 74599-88-5,77612-14-7
dl-threo-2-dichloroacetamido-1-(2-benzofuranyl)-propane-1,3-diol

Guidance literature:: With aluminum isopropoxide; In isopropyl alcohol; for 7h; Heating;
DOI:10.1002/jhet.5570170342

Reference yield:

: 23489-36-3
1-(benzofuran-2-yl)-2-bromoethan-1-one

: 74599-88-5,77612-14-7
dl-threo-2-dichloroacetamido-1-(2-benzofuranyl)-propane-1,3-diol

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / hexamethylenetetramine / CHCl₃ / 4 h / Ambient temperature

2: 23.5 g / conc. aq.HCl / ethanol / 2.5 h

3: 70 percent / 0.5 h / 80 °C

4: 33 percent / NaHCO₃ / aq. ethanol / 3.5 h / Ambient temperature

5: 21 percent / aluminium isopropoxide / propan-2-ol / 7 h / Heating

With hydrogenchloride; hexamethylenetetramine; aluminum isopropoxide; sodium hydrogencarbonate; In ethanol; chloroform; isopropyl alcohol;
DOI:10.1002/jhet.5570170342

Reference yield:

: 74599-86-3
dichloroacetamidomethyl 2-benzofuranyl ketone

: 74599-88-5,77612-14-7
dl-threo-2-dichloroacetamido-1-(2-benzofuranyl)-propane-1,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 33 percent / NaHCO₃ / aq. ethanol / 3.5 h / Ambient temperature

2: 21 percent / aluminium isopropoxide / propan-2-ol / 7 h / Heating

With aluminum isopropoxide; sodium hydrogencarbonate; In ethanol; isopropyl alcohol;
DOI:10.1002/jhet.5570170342