2,3-dihydrothiazole

Base Information

• Chemical Name: 2,3-dihydrothiazole
• CAS No.: 6569-17-1
• Molecular Formula: C₃H₅NS
• Molecular Weight: 87.1454
• Mol file: 6569-17-1.mol

Synonyms:4-Thiazoline(6CI,8CI)

Chemical Property of 2,3-dihydrothiazole

Chemical Property:

• Vapor Pressure: 0.4mmHg at 25°C
• Boiling Point: 196.4°C at 760 mmHg
• Flash Point: 72.6°C
• PSA: 37.33000
• Density: 1.124g/cm³
• LogP: 1.08030

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-dihydrothiazole

There total 4 articles about 2,3-dihydrothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

→ 1,3-thiazole (6569-17-1)

Guidance literature:

Reference yield:

C19H19NS → 1,3-thiazole (6569-17-1)

Guidance literature:

at 500 ℃; under 0.08 Torr; flash vacuum thermolysis;

DOI:10.1016/S0040-4039(00)74414-5

Reference yield:

12-(N-methyliminomethyl)-9,10-dimethyl-9,10-dihydro-11-thia-9,10-ethanoanthracene (161794-27-0) → 1,3-thiazole (6569-17-1) + 2,5-dihydro-1,3-thiazole (24576-55-4)

Guidance literature:

at 500 ℃; under 7.5006E-06 Torr; Title compound not separated from byproducts;

upstream raw materials:

12-(N-methyliminomethyl)-9,10-dimethyl-9,10-dihydro-11-thia-9,10-ethanoanthracene

Refernces

Versatile synthesis of N,S-heterocycles containing the antipyrine moiety

10.1080/104265090969054

The study, titled "Versatile Synthesis of N,S-Heterocycles Containing the Antipyrine Moiety" focuses on synthesizing novel sulfur derivatives with potential biological activity, incorporating the antipyrine moiety. The primary chemicals involved include 4-(chloroacetyl)antipyrine (1) and 4-(cyanoacetyl)antipyrine (14), which serve as key starting materials. Compound 1 reacts with various sulfur nucleophiles, such as O-ethyl xanthic acid potassium salt, 4,5-dihydrothiazole-2-thiol, and pyrimidine-2-thiol, to produce corresponding sul?de derivatives (2–5). Additionally, compound 1 reacts with 2-aminobenzothiazole to form the imidazo[2,1-b]benzothiazole derivative (7). The 2-aminothiazole derivatives (10 and 11) are synthesized via a waste-free, solid-state reaction of compound 1 with thiourea derivatives (8 and 9). These aminothiazole products are then coupled with pyrazolopyridinyl and aromatic diazonium salts to create a series of azo dyes (12 and 13). Furthermore, compound 14 reacts with phenyl isothiocyanate to form a nonisolable adduct (15), which is used as a precursor for synthesizing ketene N,S-acetal (16), dihydrothiazole (17), and thiazolidinone (18) derivatives. The study explores the reactivity of these compounds and their potential applications in medicine and pharmacology, leveraging the known pharmacological properties of antipyrine derivatives.