5-Cyclopropyl-5-phenyl-1,3-oxazolidin-2-one

Base Information

• Chemical Name: 5-Cyclopropyl-5-phenyl-1,3-oxazolidin-2-one
• CAS No.: 35200-90-9
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.241
• NSC Number: 171676
• DSSTox Substance ID: DTXSID40305788
• Mol file: 35200-90-9.mol

Synonyms:35200-90-9;5-cyclopropyl-5-phenyl-1,3-oxazolidin-2-one;NSC171676;DTXSID40305788;NSC-171676

Chemical Property of 5-Cyclopropyl-5-phenyl-1,3-oxazolidin-2-one

Chemical Property:

• Vapor Pressure: 1.79E-07mmHg at 25°C
• Boiling Point: 426.3°Cat760mmHg
• Flash Point: 211.6°C
• Density: 1.256g/cm³
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 203.094628657
• Heavy Atom Count: 15
• Complexity: 269

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1C2(CNC(=O)O2)C3=CC=CC=C3

Technology Process of 5-Cyclopropyl-5-phenyl-1,3-oxazolidin-2-one

There total 1 articles about 5-Cyclopropyl-5-phenyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-cyclopropyl-3-hydroxy-3-phenyl-propionic acid methyl ester (35200-87-4) → 5-cyclopropyl-5-phenyl-oxazolidin-2-one (35200-90-9)

Guidance literature:

Multistep reaction; (i) NH₂NH₂, MeOH, (ii) aq. HCl, NaNO₂;

DOI:10.1021/jo00986a006

Reference yield:

5-cyclopropyl-5-phenyl-oxazolidin-2-one (35200-90-9) → 5-cyclopropyl-3-nitroso-5-phenyl-oxazolidin-2-one (35200-96-5)

Guidance literature:

With acetic anhydride; nitrosylchloride; In pyridine;

DOI:10.1021/jo00986a006

Reference yield:

5-cyclopropyl-5-phenyl-oxazolidin-2-one (35200-90-9) → 2-(N-Nitrosoacetylamino)-1-cyclopropyl-1-phenylethanol (35249-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) aq. KOH, (ii) /BRN= 385737/, MeOH

2: NOCl, KOAc, P₂O₅ / acetic acid

With potassium acetate; phosphorus pentoxide; nitrosylchloride; In acetic acid;

DOI:10.1021/jo00986a006

upstream raw materials:

3-cyclopropyl-3-hydroxy-3-phenyl-propionic acid methyl ester

Downstream raw materials:

5-cyclopropyl-3-nitroso-5-phenyl-oxazolidin-2-one

2-Acetylamino-1-cyclopropyl-1-phenylaethanol

2-(N-Nitrosoacetylamino)-1-cyclopropyl-1-phenylethanol

cyclopropylphenylethyne