2-chloro-2',3'-didehydro-2',3'-dideoxyadenosine

Base Information

Chemical Name:2-chloro-2',3'-didehydro-2',3'-dideoxyadenosine
CAS No.:119530-56-2
Molecular Formula:C₁₀H₁₀ClN₅O₂
Molecular Weight:267.675
Hs Code.:
Mol file:119530-56-2.mol

Synonyms:2-Furanmethanol,5-(6-amino-2-chloro-9H-purin-9-yl)-2,5-dihydro-, (2S-cis)-

Suppliers and Price of 2-chloro-2',3'-didehydro-2',3'-dideoxyadenosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-chloro-2',3'-didehydro-2',3'-dideoxyadenosine

Chemical Property:

Boiling Point:481.1°Cat760mmHg
Flash Point:244.7°C
PSA：99.08000
Density:1.87g/cm³
LogP:1.08900

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-chloro-2',3'-didehydro-2',3'-dideoxyadenosine

There total 10 articles about 2-chloro-2',3'-didehydro-2',3'-dideoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 119530-64-2
2-Chloro-2',3'-didehydro-2',3'-dideoxy-5'-O-(4,4'-dimethoxytrityl)adenosine

: 119530-56-2
2-Chloro-2',3'-didehydro-2',3'-dideoxyadenosine

Guidance literature:: With silica gel; In benzene; for 96h; Ambient temperature;
DOI:10.1021/jm00125a031

Reference yield:

: 146-77-0
2-Chloroadenosine

: 119530-56-2
2-Chloro-2',3'-didehydro-2',3'-dideoxyadenosine

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / pyridine / 20 °C

2: acetonitrile / 20 °C

3: 1,3-dimethyl-2-phenyl-1,3-diazaphospholidine / tetrahydrofuran / 20 °C

4: TBAF on silica gel / tetrahydrofuran / 20 °C

With 1H-imidazole; 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine; tetrabutyl ammonium fluoride; In tetrahydrofuran; pyridine; acetonitrile; 2: Corey-Winter olefin synthesis / 3: Corey-Winter olefin synthesis;
DOI:10.1002/ejoc.200300274