1,2,3,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8-amine hydrate (1:1)

Base Information

• Chemical Name: 1,2,3,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8-amine hydrate (1:1)
• CAS No.: 62732-43-8
• Molecular Formula: C11H16N2O
• Molecular Weight: 192.2575
• Mol file: 62732-43-8.mol

Synonyms:

Chemical Property of 1,2,3,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8-amine hydrate (1:1)

Chemical Property:

• Vapor Pressure: 4.41E-05mmHg at 25°C
• Boiling Point: 350.4°Cat760mmHg
• Flash Point: 192.7°C
• Density: g/cm³

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8-amine hydrate (1:1)

There total 4 articles about 1,2,3,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8-amine hydrate (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1',5',6',7'-tetrahydro-spiro[cyclopentane-1,2'-cyclopentapyrimidin]-4'-one (30152-72-8) → 2‐azatricyclo[7.3.0.03,7]dodeca‐1,3(7),8‐trien‐8‐amine (62732-43-8)

Guidance literature:

With trichlorophosphate; In toluene; for 14h; Heating;

DOI:10.1007/BF00512825

Reference yield: 52.0%

cyclopentanone (120-92-3) + 2-amino-1-cyanocyclopentene (2941-23-3) → 2‐azatricyclo[7.3.0.03,7]dodeca‐1,3(7),8‐trien‐8‐amine (62732-43-8)

Guidance literature:

With zinc(II) chloride; In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; Inert atmosphere;

Reference yield:

hexanedinitrile (111-69-3) → 2‐azatricyclo[7.3.0.03,7]dodeca‐1,3(7),8‐trien‐8‐amine (62732-43-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / toluene / 8 h / 65 - 80 °C / Inert atmosphere

2: zinc(II) chloride / 5,5-dimethyl-1,3-cyclohexadiene / 140 °C / Inert atmosphere

With potassium tert-butylate; zinc(II) chloride; In 5,5-dimethyl-1,3-cyclohexadiene; toluene;

upstream raw materials:

cyclopentanone

2-amino-1-cyanocyclopentene

1',5',6',7'-tetrahydro-spiro[cyclopentane-1,2'-cyclopentapyrimidin]-4'-one

hexanedinitrile

Refernces

• 1、 Upadysheva et al.. "-". . . Retrieved 1977.
• 2、 -. "NLRP MODULATORS". Page/Page column 346; 369-370. . Retrieved 2020/01/31.
• 3、 -. "COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY". Page/Page column 283. . Retrieved 2020/06/05.