Chemical Property of Iberiotoxin
Chemical Property:
- Boiling Point:°Cat760mmHg
- Flash Point:°C
- PSA：0.00000
- Density:g/cm3
- LogP:0.00000
- Storage Temp.:−20°C
- Solubility.:H2O: 1 mg/mL, clear, colorless
- XLogP3:-22
- Hydrogen Bond Donor Count:61
- Hydrogen Bond Acceptor Count:69
- Rotatable Bond Count:100
- Exact Mass:4228.8259161
- Heavy Atom Count:291
- Complexity:9970
- Purity/Quality:
-
98%,99%, *data from raw suppliers
Iberiotoxin *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:T+
- Statements:
26/27/28
- Safety Statements:
28-36/37-45
- MSDS Files:
-
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CC(C)CC1C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)CC(=O)O)CCCCN)NC(=O)C(C(C)C)NC(=O)C(CO)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C4CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N4)CCC(=O)O)CCCCN)CO)C(C)C)CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)C6CCC(=O)N6)C(=O)NC(CCSC)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC7CSSCC(NC(=O)C(NC7=O)CCCNC(=N)N)C(=O)NC(CC8=CC=C(C=C8)O)C(=O)NC(CCC(=O)N)C(=O)O)CCCCN)CCCNC(=N)N)CC(=O)O)C(C)C)CC9=CC=CC=C9
-
Uses
Selective probe for high-conductance calcium-activated potassium channels. Iberiotoxin is a selective and reversible inhibitor of high-conductance calcium-activated potassium channel. A toxin purified from the Eastern Indian red scorpion Buthus tamulus. Iberiotoxin, recombinant from Mesobuthus tamulus has been used as an inhibitor of large-conductance calcium-activated K+ channels to study its effect on the NLRP3 (nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3) inflammasome activation in bone marrow-derived macrophages (BMDMs). It has also been used to block Ca2+- activated K+ channels to determine interleukin(IL)-1β in BMDCs following inflammasome activation.
