Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-(3-nitrophenyl)-

Base Information

• Chemical Name: Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-(3-nitrophenyl)-
• CAS No.: 6646-49-7
• Molecular Formula: C11H11 N3 O2 S
• Molecular Weight: 249.293
• Mol file: 6646-49-7.mol

Synonyms:Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-(m-nitrophenyl)- (7CI,8CI); Nitramisole

Chemical Property of Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-(3-nitrophenyl)-

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-(3-nitrophenyl)-

There total 5 articles about Imidazo[2,1-b]thiazole,2,3,5,6-tetrahydro-6-(3-nitrophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H13N3O3S (82191-15-9) → l-6-(m-nitrophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (6646-49-7,6363-02-6)

Guidance literature:

C₁₁H₁₃N₃O₃S; With thionyl chloride; In 1,2-dichloro-ethane; at 20 ℃;

With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane; at 40 ℃; for 6h;

Reference yield:

3'-nitro-2-bromoacetophenone (2227-64-7) → l-6-(m-nitrophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (6646-49-7,6363-02-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile / 0.5 h / Heating

2: Py / CHCl₃ / 1.5 h / Heating

3: (i) SOCl₂, (ii) Ac₂O

With pyridine; In chloroform; acetonitrile;

DOI:10.1021/jm00322a023

Reference yield:

2-(2-imino-thiazolidin-3-yl)-1-(3-nitro-phenyl)-ethanone (83846-64-4) → l-6-(m-nitrophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (6646-49-7,6363-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Py / CHCl₃ / 1.5 h / Heating

2: (i) SOCl₂, (ii) Ac₂O

With pyridine; In chloroform;

DOI:10.1021/jm00322a023

upstream raw materials:

2-(2-acetylimino-thiazolidin-3-yl)-1-(3-nitro-phenyl)-ethanone

2-(2-imino-thiazolidin-3-yl)-1-(3-nitro-phenyl)-ethanone

3'-nitro-2-bromoacetophenone

C₁₁H₁₃N₃O₃S

Downstream raw materials:

(6R)-(3-nitrophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole

(6S)-(3-nitrophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole

Refernces

• 1、 -. "6-Substituted amino phenyl-2,3,5,6-tetrahydro[2,1-b]thiazoles". . . Retrieved 2008/06/13.