11,9-Epoxymethanoprostaglandin H1

Base Information

• Chemical Name: 11,9-Epoxymethanoprostaglandin H1
• CAS No.: 72517-81-8
• Molecular Formula: C₂₁H₃₆O₄
• Molecular Weight: 352.514
• Mol file: 72517-81-8.mol

Synonyms:11,9-epoxymethano-PGH1;11,9-epoxymethanoprostaglandin H1

Chemical Property of 11,9-Epoxymethanoprostaglandin H1

Chemical Property:

• Vapor Pressure: 6.05E-13mmHg at 25°C
• Boiling Point: 519.1°Cat760mmHg
• Flash Point: 174.9°C
• PSA: 66.76000
• Density: 1.077g/cm³
• LogP: 4.56010
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 13
• Exact Mass: 352.26135963
• Heavy Atom Count: 25
• Complexity: 420

Purity/Quality:

99% ^*data from raw suppliers

9,11-methane-epoxy Prostaglandin F1α ≥96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCC(C=CC1C2CC(C1CCCCCCC(=O)O)CO2)O
• Isomeric SMILES: CCCCC[C@@H](/C=C/[C@H]1[C@@H]2C[C@H]([C@@H]1CCCCCCC(=O)O)CO2)O

Technology Process of 11,9-Epoxymethanoprostaglandin H1

There total 2 articles about 11,9-Epoxymethanoprostaglandin H1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-9-deoxy-9α-p-toluenesulfonyloxymethyl PGF1α methyl ester (75584-00-8) → (+/-)-11α,9α-epoxymethano-15α-hydroxy-prost-13E-enoic acid (72517-81-8)

Guidance literature:

With potassium hydroxide; In methanol; water; for 4h; Yield given;

DOI:10.1248/cpb.28.1814

Reference yield:

7-[(1R,2S,3S,5R)-3-Hydroxy-5-hydroxymethyl-2-((E)-(R)-3-hydroxy-oct-1-enyl)-cyclopentyl]-heptanoic acid methyl ester → (+/-)-11α,9α-epoxymethano-15α-hydroxy-prost-13E-enoic acid (72517-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 5percent KOH / methanol; H₂O / 4 h

2: 5percent KOH / methanol; H₂O / 4 h

With potassium hydroxide; In methanol; water;

DOI:10.1248/cpb.28.1814

upstream raw materials:

(+/-)-9-deoxy-9α-p-toluenesulfonyloxymethyl PGF_1α methyl ester

Refernces