6-Methoxy-1-methyl-2(1H)-quinolinone

Base Information

• Chemical Name: 6-Methoxy-1-methyl-2(1H)-quinolinone
• CAS No.: 5392-11-0
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.214
• Hs Code.: 2933790090
• NSC Number: 3255
• UNII: ILE1R3Z4XC
• DSSTox Substance ID: DTXSID20202201
• Nikkaji Number: J2.797.529A
• Wikidata: Q83075473
• Mol file: 5392-11-0.mol

Synonyms:5392-11-0;6-Methoxy-1-methylquinolin-2(1H)-one;6-Methoxy-1-methyl-2(1H)-quinolinone;6-methoxy-1-methylquinolin-2-one;NSC3255;ILE1R3Z4XC;6-METHOXY-1-METHYL-1H-QUINOLIN-2-ONE;NSC 3255;NSC-3255;2(1H)-Quinolinone, 6-methoxy-1-methyl-;UNII-ILE1R3Z4XC;SCHEMBL6074279;DTXSID20202201;6-methoxy-1-methyl-quinolin-2-one;AKOS006330213;SB68076;1-Methyl-6-methoxyquinoline-2(1H)-one;6-methoxy-1-methyl-1,2-dihydroquinolin-2-one

Chemical Property of 6-Methoxy-1-methyl-2(1H)-quinolinone

Chemical Property:

• Vapor Pressure: 0.000374mmHg at 25°C
• Refractive Index: 1.573
• Boiling Point: 317.9 °C at 760 mmHg
• Flash Point: 146.1 °C
• PSA: 31.23000
• Density: 1.174 g/cm³
• LogP: 1.54710
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 189.078978594
• Heavy Atom Count: 14
• Complexity: 262

Purity/Quality:

99% ^*data from raw suppliers

6-Methoxy-1-methylquinolin-2(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=C(C=CC1=O)C=C(C=C2)OC

Technology Process of 6-Methoxy-1-methyl-2(1H)-quinolinone

There total 3 articles about 6-Methoxy-1-methyl-2(1H)-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

cis-N-(4-methoxyphenyl)-N-methyl-3-(phenylsulfanyl)acrylamide (326479-46-3) → 6-Methoxy-1-methyl-2-oxo-1,2-dihydroquinoline (5392-11-0) + N-(4-methoxyphenyl)-N-methyl-3,3-di(phenylsulfanyl)propionamide

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 14h; Heating;

DOI:10.1248/cpb.48.1854

Reference yield: 54.0%

trans-N-(4-methoxyphenyl)-N-methyl-3-(phenylsulfanyl)acrylamide (326479-47-4) → 6-Methoxy-1-methyl-2-oxo-1,2-dihydroquinoline (5392-11-0) + N-(4-methoxyphenyl)-N-methyl-3,3-di(phenylsulfanyl)propionamide

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 14h; Heating;

DOI:10.1248/cpb.48.1854

Reference yield: 20.0%

C15H18N4O2 (1210820-24-8) → 6-Methoxy-1-methyl-2-oxo-1,2-dihydroquinoline (5392-11-0) + C15H20N4O2 (1210820-46-4) + C15H18N4O2 (1210820-45-3) + C15H18N4O2 (1210820-44-2) + 3,5-dimethyl-4H-1,2,4-triazole (7343-34-2)

Guidance literature:

With triethylamine; In methanol; at 20 ℃; for 0.5h; Irradiation;

DOI:10.3987/COM-09-S(S)55

upstream raw materials:

cis-N-(4-methoxyphenyl)-N-methyl-3-(phenylsulfanyl)acrylamide

trans-N-(4-methoxyphenyl)-N-methyl-3-(phenylsulfanyl)acrylamide

C₁₅H₁₈N₄O₂

Downstream raw materials:

2-chloro-6-methoxyquinoline

6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline

(E)-3-{4-[Hydroxy-(6-methoxy-1-methyl-1,2,3,4-tetrahydro-quinolin-3-ylmethoxy)-phosphoryl]-phenyl}-acrylic acid isopropyl ester

6-hydroxy-1-methyl-2-quinolinone