5-Amino-2-(methylthio)-1,3-thiazole-4-carboxamide

Base Information

Chemical Name:5-Amino-2-(methylthio)-1,3-thiazole-4-carboxamide
CAS No.:52868-69-6
Molecular Formula:C5H7N3OS2
Molecular Weight:189.2586
Hs Code.:
NSC Number:135087
DSSTox Substance ID:DTXSID90300142
Wikidata:Q82042979
ChEMBL ID:CHEMBL459219
Mol file:52868-69-6.mol

Synonyms:52868-69-6;5-amino-2-(methylthio)-1,3-thiazole-4-carboxamide;5-amino-2-methylsulfanyl-1,3-thiazole-4-carboxamide;NSC 135087;NSC135087;Maybridge3_000702;Oprea1_831824;CHEMBL459219;SCHEMBL18337153;DTXSID90300142;HMS1432P20;CCG-52956;NSC-135087;IDI1_012089;4-Thiazolecarboxamide, 5-amino-2-methylthio-;SR-01000642153-1

Suppliers and Price of 5-Amino-2-(methylthio)-1,3-thiazole-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 5-Amino-2-(methylthio)-1,3-thiazole-4-carboxamide

Chemical Property:

Vapor Pressure:2.45E-07mmHg at 25°C
Boiling Point:422.3°Cat760mmHg
Flash Point:209.2°C
PSA：135.54000
Density:1.52g/cm³
LogP:1.82760
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:189.00305420
Heavy Atom Count:11
Complexity:166

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CSC1=NC(=C(S1)N)C(=O)N

Technology Process of 5-Amino-2-(methylthio)-1,3-thiazole-4-carboxamide

There total 4 articles about 5-Amino-2-(methylthio)-1,3-thiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 52868-63-0
5-amino-2-mercaptothiazole-4-carboxamide

: 77-78-1
dimethyl sulfate

: 52868-69-6
5-amino-2-methylthiothiazole-4-carboxamide

Guidance literature:: With sodium hydroxide; In water; for 1h; Cooling;
DOI:10.1515/hc-2014-0054

Reference yield:

: 5-amino-N-(2,4-dimethoxybenzyl)-2-methylsulfanyl-1,3-thiazole-4-carboxamide

: 52868-69-6
5-amino-2-methylthiothiazole-4-carboxamide

Guidance literature:: With triethylsilane; trifluoroacetic acid; at 20 ℃; for 1h;

Reference yield:

: 5-amino-2-methylsulfanyl-1,3-thiazole-4-carboxylic acid

: 52868-69-6
5-amino-2-methylthiothiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / water; N,N-dimethyl-formamide / 20 °C

2: triethylsilane; trifluoroacetic acid / 1 h / 20 °C

With triethylsilane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In water; N,N-dimethyl-formamide;