dipropan-2-yl (chloromethyl)phosphonate

Base Information

• Chemical Name: dipropan-2-yl (chloromethyl)phosphonate
• CAS No.: 6954-83-2
• Molecular Formula: C7H16 Cl O3 P
• Molecular Weight: 214.6269
• Mol file: 6954-83-2.mol

Synonyms:Phosphonicacid, (chloromethyl)-, bis(1-methylethyl) ester (9CI); Phosphonic acid,(chloromethyl)-, diisopropyl ester (6CI); Diisopropyl(chloromethyl)phosphonate; NSC 67754

Chemical Property of dipropan-2-yl (chloromethyl)phosphonate

Chemical Property:

• Vapor Pressure: 0.0378mmHg at 25°C
• Boiling Point: 248.7°Cat760mmHg
• Flash Point: 107.7°C
• Density: 1.111g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of dipropan-2-yl (chloromethyl)phosphonate

There total 1 articles about dipropan-2-yl (chloromethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

isopropyl alcohol (67-63-0,8013-70-5) + chloromethylphosphonic dichloride (1983-26-2) → diisopropyl α-chloromethylphosphonate (6954-83-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 2h; Ambient temperature;

Reference yield: 56.0%

diisopropyl α-chloromethylphosphonate (6954-83-2) + tert-butyl cinnamate (14990-09-1) → (+/-)-(1R,2S,3R)-tert-butyl 2-(diisopropoxyphosphoryl)-3-phenyl cyclopropanecarboxylate + (+/-)-(1S,2S,3S)-tert-butyl 2-(diisopropoxyphosphoryl)-3-phenyl cyclopropanecarboxylate

Guidance literature:

diisopropyl α-chloromethylphosphonate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.25h;

tert-butyl cinnamate; In tetrahydrofuran; at -78 ℃; for 1.75h; Further stages.;

DOI:10.1016/j.bmc.2007.02.040

Reference yield:

diisopropyl α-chloromethylphosphonate (6954-83-2) → O-ethylchloromethylphosphonic acid (1929-42-6) + phenylsulfanylmethyl-phosphonic acid monoethyl ester (747407-63-2)

Guidance literature:

With sodium ethanolate; thiophenol; In ethanol; at 70 ℃; for 2h;

upstream raw materials:

isopropyl alcohol

chloromethylphosphonic dichloride

Downstream raw materials:

O-ethylchloromethylphosphonic acid

phenylsulfanylmethyl-phosphonic acid monoethyl ester

(E)-diphenyl 1-chloro 1,2-propenylphosphine oxide

(Z)-diphenyl 1-chloro 1,2-propenylphosphine oxide